Assay Detail
Binding
CHEMBL4220758
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Inhibition of AChE (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
In silico studies, synthesis and pharmacological evaluation to explore multi-targeted approach for imidazole analogues as potential cholinesterase inhibitors with neuroprotective role for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.78 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL709 | ALFUZOSIN | 4.0 | 1 | 7.75 |
| CHEMBL1201217 | DYCLONINE | 4.0 | 1 | 6.74 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 6.66 |
| CHEMBL623 | NEFAZODONE | 4.0 | 1 | 5.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL709 | ALFUZOSIN | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1201217 | DYCLONINE | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL623 | NEFAZODONE | IC50 | = | 1037.0 | nM | 5.98 |