Assay Detail
Binding
CHEMBL5577493
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse TRPV3 expressed in HEK293 cells assessed as reduction in 2-APB evoked current at -60 mV holding potential by whole-cell patch clamp method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily V member 3 (CHEMBL3879838) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
A Diterpenoid of the Medicinal Plant <i>Andrographis paniculata</i> Targets Cutaneous TRPV3 Channel and Relieves Itch.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.50 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1201217 | DYCLONINE | 4.0 | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1201217 | DYCLONINE | IC50 | = | 3200.0 | nM | 5.50 |