Assay Detail
Binding
CHEMBL3375245
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Inhibition of recombinant human BChE by Ellman method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.02 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.92 |
| CHEMBL3338394 | — | — | 1 | 7.89 |
| CHEMBL3338391 | — | — | 1 | 7.68 |
| CHEMBL636 | RIVASTIGMINE | 4.0 | 1 | 7.52 |
| CHEMBL129837 | 4-ISOPROPYLPHENSERINE | — | 1 | 7.30 |
| CHEMBL3338395 | — | — | 1 | 6.78 |
| CHEMBL1206 | ETHOPROPAZINE | 4.0 | 1 | 6.52 |
| CHEMBL3338392 | — | — | 1 | 5.87 |
| CHEMBL3338393 | — | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3338394 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3338391 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL636 | RIVASTIGMINE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL129837 | 4-ISOPROPYLPHENSERINE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3338395 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL1206 | ETHOPROPAZINE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3338392 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL3338393 | — | IC50 | = | 2150.0 | nM | 5.67 |