Assay Detail
Binding
CHEMBL4410784
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Inhibition of BChE (unknown origin) incubated for 10 mins by Ellman's method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent and selective butyrylcholinesterase inhibitors through the use of pharmacophore-based screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.77 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4473127 | — | — | 1 | 8.00 |
| CHEMBL4473505 | — | — | 1 | 7.50 |
| CHEMBL4579590 | — | — | 1 | 7.40 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.18 |
| CHEMBL1206 | ETHOPROPAZINE | 4.0 | 1 | 6.68 |
| CHEMBL1410004 | — | — | 1 | 6.01 |
| CHEMBL4564473 | — | — | 1 | 5.87 |
| CHEMBL4563313 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4473127 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4473505 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4579590 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL95 | TACRINE | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL1206 | ETHOPROPAZINE | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1410004 | — | IC50 | = | 987.0 | nM | 6.01 |
| CHEMBL4564473 | — | IC50 | = | 1365.0 | nM | 5.87 |
| CHEMBL4563313 | — | IC50 | = | 3026.0 | nM | 5.52 |