Assay Detail
Binding
CHEMBL4009597
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Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assay
30
Total Activities
29
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.03 | 5.81 |
| Inhibition | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL73234 | CARBETAPENTANE | 4.0 | 1 | 5.81 |
| CHEMBL290106 | BITHIONOL | 4.0 | 1 | 5.65 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 5.58 |
| CHEMBL12131 | CLOSANTEL | 2.0 | 1 | 5.52 |
| CHEMBL723 | CARVEDILOL | 4.0 | 1 | 5.47 |
| CHEMBL926 | DOBUTAMINE | 4.0 | 1 | 5.38 |
| CHEMBL420 | GUANABENZ | 4.0 | 1 | 5.31 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 5.21 |
| CHEMBL562 | GRISEOFULVIN | 4.0 | 1 | 5.14 |
| CHEMBL11 | IMIPRAMINE | 4.0 | 1 | 5.10 |
| CHEMBL33845 | DICHLOROPHEN | 2.0 | 1 | 5.08 |
| CHEMBL253592 | CAMYLOFIN | 2.0 | 1 | 5.04 |
| CHEMBL72 | DESIPRAMINE | 4.0 | 1 | 5.04 |
| CHEMBL52440 | DEXTROMETHORPHAN | 4.0 | 1 | 4.98 |
| CHEMBL1628227 | DOXEPIN | 4.0 | 1 | 4.95 |
| CHEMBL104 | CLOTRIMAZOLE | 4.0 | 1 | 4.92 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 4.87 |
| CHEMBL709 | ALFUZOSIN | 4.0 | 1 | 4.83 |
| CHEMBL415087 | CLOPERASTINE | 2.0 | 1 | 4.83 |
| CHEMBL631 | PROPAFENONE | 4.0 | 1 | 4.81 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 4.79 |
| CHEMBL134 | CLONIDINE | 4.0 | 1 | 4.72 |
| CHEMBL1206 | ETHOPROPAZINE | 4.0 | 1 | 4.69 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 4.66 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 4.29 |
| CHEMBL21640 | — | — | 1 | 4.09 |
| CHEMBL1547 | THIAMINE ION | 4.0 | 2 | - |
| CHEMBL1431 | METFORMIN | 4.0 | 1 | - |
| CHEMBL30 | CIMETIDINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL73234 | CARBETAPENTANE | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL290106 | BITHIONOL | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL12131 | CLOSANTEL | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL723 | CARVEDILOL | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL926 | DOBUTAMINE | IC50 | = | 4170.0 | nM | 5.38 |
| CHEMBL420 | GUANABENZ | IC50 | = | 4850.0 | nM | 5.31 |
| CHEMBL535 | SUNITINIB | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL562 | GRISEOFULVIN | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL11 | IMIPRAMINE | IC50 | = | 7950.0 | nM | 5.10 |
| CHEMBL33845 | DICHLOROPHEN | IC50 | = | 8410.0 | nM | 5.08 |
| CHEMBL253592 | CAMYLOFIN | IC50 | = | 9120.0 | nM | 5.04 |
| CHEMBL72 | DESIPRAMINE | IC50 | = | 9180.0 | nM | 5.04 |
| CHEMBL52440 | DEXTROMETHORPHAN | IC50 | = | 10450.0 | nM | 4.98 |
| CHEMBL1628227 | DOXEPIN | IC50 | = | 11190.0 | nM | 4.95 |
| CHEMBL104 | CLOTRIMAZOLE | IC50 | = | 11970.0 | nM | 4.92 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 13570.0 | nM | 4.87 |
| CHEMBL709 | ALFUZOSIN | IC50 | = | 14870.0 | nM | 4.83 |
| CHEMBL415087 | CLOPERASTINE | IC50 | = | 14890.0 | nM | 4.83 |
| CHEMBL631 | PROPAFENONE | IC50 | = | 15540.0 | nM | 4.81 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL134 | CLONIDINE | IC50 | = | 18980.0 | nM | 4.72 |
| CHEMBL1206 | ETHOPROPAZINE | IC50 | = | 20460.0 | nM | 4.69 |
| CHEMBL95 | TACRINE | IC50 | = | 21720.0 | nM | 4.66 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 50680.0 | nM | 4.29 |
| CHEMBL21640 | — | IC50 | = | 82100.0 | nM | 4.09 |
| CHEMBL1547 | THIAMINE ION | Inhibition | = | -1.5 | % | - |
| CHEMBL1547 | THIAMINE ION | IC50 | = | 4354000.0 | nM | - |
| CHEMBL1431 | METFORMIN | Inhibition | = | 11.1 | % | - |
| CHEMBL30 | CIMETIDINE | Inhibition | = | 4.13 | % | - |