Compound Detail
CHEMBL253592
CAMYLOFIN 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL253592 |
| Name | CAMYLOFIN |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | RYOOHIUJEJZCFT-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
10
Publications
4
Known Names
1
Indications
Molecular Properties
320.5
MW (Da)
3.25
ALogP
4
HBA
1
HBD
41.6
PSA (Ų)
0.64
QED
0
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Indications
Digestive System Diseases
ATC Classification
A03AA03
camylofin
Level 1: ALIMENTARY TRACT AND METABOLISM
Level 2: DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
Activity Summary
IC50 2 meas. best 5.04
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Solute carrier family 22 member 1 CHEMBL5685 | IC50 | 5.04 | 5.04 | 9120.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.61 | 4.61 | 24771.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Solute carrier family 22 member 1 | IC50 | = | 9120.0 | nM | 5.04 | Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptak... | 28230985 |
| Unchecked | IC50 | = | 24771.66 | nM | 4.61 | PubChem BioAssay. insulin secretion from INS-1E cells in the presence of 5 mM gl... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.5281/zenodo.13943903 | ADMET | 89 |
| 31158845 | 10.1038/s41586-019-1291-3 | ADMET | 55 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 18027916 | 10.1021/jm070524a | Sphingomyelin phosphodiesterase | 1 |
| 28230985 | 10.1021/acs.jmedchem.6b01317 | Solute carrier family 22 member 1 | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
| 38318365 | 10.1016/j.isci.2024.108907 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 1 |
Data from ChEMBL 36 via Core Engine