Assay Detail
Functional
CHEMBL3562017
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PubChem BioAssay. insulin secretion from INS-1E cells in the presence of 5 mM glucose-IC50. (Class of assay: confirmatory)
120
Total Activities
120
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | INS-1E |
| Category | confirmatory |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 120 | 5.20 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1481 | GLIMEPIRIDE | 4.0 | 1 | 8.39 |
| CHEMBL472 | GLYBURIDE | 4.0 | 1 | 8.09 |
| CHEMBL356866 | — | — | 1 | 7.57 |
| CHEMBL383634 | GLIQUIDONE | 2.0 | 1 | 6.64 |
| CHEMBL427216 | GLICLAZIDE | 3.0 | 1 | 5.74 |
| CHEMBL1446650 | MEBEVERINE HYDROCHLORIDE | -1.0 | 1 | 5.71 |
| CHEMBL1201245 | BROMODIPHENHYDRAMINE | 4.0 | 1 | 5.56 |
| CHEMBL93240 | METITEPINE | 2.0 | 1 | 5.53 |
| CHEMBL1200964 | AMITRIPTYLINE HYDROCHLORIDE | 4.0 | 1 | 5.52 |
| CHEMBL2110816 | BUTRIPTYLINE | 2.0 | 1 | 5.44 |
| CHEMBL1200638 | DEXBROMPHENIRAMINE MALEATE | 4.0 | 1 | 5.42 |
| CHEMBL1518149 | INDOCATE | 2.0 | 1 | 5.42 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 5.41 |
| CHEMBL1736151 | ETAFENONE | 2.0 | 1 | 5.41 |
| CHEMBL2105615 | QUINACRINE HYDROCHLORIDE | -1.0 | 1 | 5.39 |
| CHEMBL2110839 | DORASTINE | 2.0 | 1 | 5.38 |
| CHEMBL1200395 | ORPHENADRINE CITRATE | 4.0 | 1 | 5.36 |
| CHEMBL631 | PROPAFENONE | 4.0 | 1 | 5.31 |
| CHEMBL1200322 | ESCITALOPRAM OXALATE | 4.0 | 1 | 5.26 |
| CHEMBL1194287 | CHLOROPYRAMINE | 2.0 | 1 | 5.21 |
| CHEMBL817 | TOLAZAMIDE | 4.0 | 1 | 5.16 |
| CHEMBL1172 | DESLORATADINE | 4.0 | 1 | 5.15 |
| CHEMBL783 | NATEGLINIDE | 4.0 | 1 | 5.15 |
| CHEMBL2104501 | APRINDINE HYDROCHLORIDE | -1.0 | 1 | 5.15 |
| CHEMBL73234 | CARBETAPENTANE | 4.0 | 1 | 5.11 |
| CHEMBL2355333 | ZIMELDINE HYDROCHLORIDE | 4.0 | 1 | 5.08 |
| CHEMBL2356801 | — | — | 1 | 5.08 |
| CHEMBL2359025 | — | — | 1 | 5.03 |
| CHEMBL2104103 | CLOCAPRAMINE | 2.0 | 1 | 5.00 |
| CHEMBL126075 | DILAZEP | 2.0 | 1 | 4.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1481 | GLIMEPIRIDE | IC50 | = | 4.06 | nM | 8.39 |
| CHEMBL472 | GLYBURIDE | IC50 | = | 8.08 | nM | 8.09 |
| CHEMBL356866 | — | IC50 | = | 27.04 | nM | 7.57 |
| CHEMBL383634 | GLIQUIDONE | IC50 | = | 229.87 | nM | 6.64 |
| CHEMBL427216 | GLICLAZIDE | IC50 | = | 1833.95 | nM | 5.74 |
| CHEMBL1446650 | MEBEVERINE HYDROCHLORIDE | IC50 | = | 1951.67 | nM | 5.71 |
| CHEMBL1201245 | BROMODIPHENHYDRAMINE | IC50 | = | 2767.44 | nM | 5.56 |
| CHEMBL93240 | METITEPINE | IC50 | = | 2944.41 | nM | 5.53 |
| CHEMBL1200964 | AMITRIPTYLINE HYDROCHLORIDE | IC50 | = | 2999.14 | nM | 5.52 |
| CHEMBL2110816 | BUTRIPTYLINE | IC50 | = | 3638.2 | nM | 5.44 |
| CHEMBL1518149 | INDOCATE | IC50 | = | 3844.58 | nM | 5.42 |
| CHEMBL1200638 | DEXBROMPHENIRAMINE MALEATE | IC50 | = | 3759.92 | nM | 5.42 |
| CHEMBL1736151 | ETAFENONE | IC50 | = | 3892.46 | nM | 5.41 |
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 3867.4 | nM | 5.41 |
| CHEMBL2105615 | QUINACRINE HYDROCHLORIDE | IC50 | = | 4068.39 | nM | 5.39 |
| CHEMBL2110839 | DORASTINE | IC50 | = | 4201.38 | nM | 5.38 |
| CHEMBL1200395 | ORPHENADRINE CITRATE | IC50 | = | 4348.34 | nM | 5.36 |
| CHEMBL631 | PROPAFENONE | IC50 | = | 4918.82 | nM | 5.31 |
| CHEMBL1200322 | ESCITALOPRAM OXALATE | IC50 | = | 5446.64 | nM | 5.26 |
| CHEMBL1194287 | CHLOROPYRAMINE | IC50 | = | 6140.8 | nM | 5.21 |
| CHEMBL817 | TOLAZAMIDE | IC50 | = | 6976.89 | nM | 5.16 |
| CHEMBL783 | NATEGLINIDE | IC50 | = | 7074.26 | nM | 5.15 |
| CHEMBL2104501 | APRINDINE HYDROCHLORIDE | IC50 | = | 7127.9 | nM | 5.15 |
| CHEMBL1172 | DESLORATADINE | IC50 | = | 7105.44 | nM | 5.15 |
| CHEMBL73234 | CARBETAPENTANE | IC50 | = | 7686.96 | nM | 5.11 |
| CHEMBL2355333 | ZIMELDINE HYDROCHLORIDE | IC50 | = | 8361.09 | nM | 5.08 |
| CHEMBL2356801 | — | IC50 | = | 8410.3 | nM | 5.08 |
| CHEMBL2359025 | — | IC50 | = | 9257.02 | nM | 5.03 |
| CHEMBL2104103 | CLOCAPRAMINE | IC50 | = | 10082.31 | nM | 5.00 |
| CHEMBL126075 | DILAZEP | IC50 | = | 10157.06 | nM | 4.99 |
| CHEMBL3182267 | — | IC50 | = | 10778.5 | nM | 4.97 |
| CHEMBL1256661 | PROPIONYLPROMAZINE HYDROCHLORIDE | IC50 | = | 10731.07 | nM | 4.97 |
| CHEMBL1883146 | ACEPROMAZINE MALEATE | IC50 | = | 11383.52 | nM | 4.94 |
| CHEMBL1898637 | — | IC50 | = | 11701.2 | nM | 4.93 |
| CHEMBL219916 | DOMPERIDONE | IC50 | = | 12428.34 | nM | 4.91 |
| CHEMBL2107408 | GLYBUZOLE | IC50 | = | 13131.8 | nM | 4.88 |
| CHEMBL357995 | BOPINDOLOL | IC50 | = | 14602.6 | nM | 4.84 |
| CHEMBL114655 | NYLIDRIN | IC50 | = | 14475.91 | nM | 4.84 |
| CHEMBL2105083 | GLYCLOPYRAMIDE | IC50 | = | 14871.75 | nM | 4.83 |
| CHEMBL321582 | BUCINDOLOL | IC50 | = | 15011.9 | nM | 4.82 |
| CHEMBL2105183 | OBERADILOL | IC50 | = | 15154.66 | nM | 4.82 |
| CHEMBL298406 | ECOPIPAM | IC50 | = | 15364.92 | nM | 4.81 |
| CHEMBL511 | PYRILAMINE | IC50 | = | 15361.36 | nM | 4.81 |
| CHEMBL1200654 | BENOXINATE HYDROCHLORIDE | IC50 | = | 15505.47 | nM | 4.81 |
| CHEMBL1615867 | AZACLORZINE | IC50 | = | 16755.16 | nM | 4.78 |
| CHEMBL76370 | TEGASEROD | IC50 | = | 16844.2 | nM | 4.77 |
| CHEMBL95 | TACRINE | IC50 | = | 17611.19 | nM | 4.75 |
| CHEMBL3183101 | — | IC50 | = | 17749.02 | nM | 4.75 |
| CHEMBL1511957 | PIPERIDOLATE HYDROCHLORIDE | IC50 | = | 18226.7 | nM | 4.74 |
| CHEMBL1308088 | — | IC50 | = | 18513.49 | nM | 4.73 |