Compound Detail
CHEMBL1194287
CHLOROPYRAMINE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL1194287 |
| Name | CHLOROPYRAMINE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | ICKFFNBDFNZJSX-UHFFFAOYSA-N |
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
20
Publications
3
Known Names
2
Indications
Molecular Properties
289.8
MW (Da)
3.30
ALogP
3
HBA
0
HBD
19.4
PSA (Ų)
0.81
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Indications
Hypersensitivity Pruritus
ATC Classification
D04AA09
chloropyramine
Level 1: DERMATOLOGICALS
Level 2: ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
R06AC03
chloropyramine
Level 1: RESPIRATORY SYSTEM
Level 2: ANTIHISTAMINES FOR SYSTEMIC USE
R06AC53
chloropyramine, combinations
Level 1: RESPIRATORY SYSTEM
Level 2: ANTIHISTAMINES FOR SYSTEMIC USE
Activity Summary
IC50 5 meas. best 5.32
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 5.32 | 5.1033 | 4782.3 | 3 |
| MDA-MB-157 CHEMBL1075496 | IC50 | 4.37 | 4.37 | 43060.0 | 1 |
| MDA-MB-231 CHEMBL400 | IC50 | 4.3 | 4.3 | 49730.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 4782.27 | nM | 5.32 | PubChem BioAssay. tonic K+ channel activity under 0.1 mM glucose conditions in I... | - |
| Unchecked | IC50 | = | 6140.8 | nM | 5.21 | PubChem BioAssay. insulin secretion from INS-1E cells in the presence of 5 mM gl... | - |
| Unchecked | IC50 | = | 16790.4 | nM | 4.78 | PubChem BioAssay. insulin secretion from INS-1E cells in the presence of 0.1 mM ... | - |
| MDA-MB-157 | IC50 | = | 43060.0 | nM | 4.37 | Antiproliferative activity against human MDA-MB-157 cells assessed as inhibition... | 35569251 |
| MDA-MB-231 | IC50 | = | 49730.0 | nM | 4.3 | Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition... | 35569251 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Thromboxane A2 receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Prostaglandin G/H synthase 1 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Alpha-1A adrenergic receptor | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Sodium-dependent noradrenaline transporter | 1 |
| - | 10.1101/2020.04.21.054387 | SARS-CoV-2 | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Vascular endothelial growth factor receptor 2 | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | 5-hydroxytryptamine receptor 1A | 1 |
| 35569251 | 10.1016/j.bmc.2022.116809 | MDA-MB-231 | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Mu-type opioid receptor | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Alpha-2A adrenergic receptor | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Sodium-dependent serotonin transporter | 1 |
| 35569251 | 10.1016/j.bmc.2022.116809 | MDA-MB-157 | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Acetylcholinesterase | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Estrogen receptor | 1 |
| 38318365 | 10.1016/j.isci.2024.108907 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | D(1A) dopamine receptor | 1 |
| 35569251 | 10.1016/j.bmc.2022.116809 | MCF-10A | 1 |
Data from ChEMBL 36 via Core Engine