Compound Detail
CHEMBL1446650
MEBEVERINE HYDROCHLORIDE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL1446650 |
| Name | MEBEVERINE HYDROCHLORIDE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PLGQWYOULXPJRE-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
| Parent Compound | CHEMBL282121 |
| Active Moiety | CHEMBL282121 |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
9
Known Names
Molecular Properties
429.6
MW (Da)
4.60
ALogP
6
HBA
0
HBD
57.2
PSA (Ų)
0.34
QED
0
Ro5 Violations
13
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Activity Summary
IC50 2 meas. best 5.76
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 5.76 | 5.735 | 1737.1 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 1737.07 | nM | 5.76 | PubChem BioAssay. tonic K+ channel activity under 0.1 mM glucose conditions in I... | - |
| Unchecked | IC50 | = | 1951.67 | nM | 5.71 | PubChem BioAssay. insulin secretion from INS-1E cells in the presence of 5 mM gl... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B1 | 1 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B3 | 1 |
| - | 10.1101/2020.04.03.023846 | SARS-CoV-2 | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
Data from ChEMBL 36 via Core Engine