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Compound Detail

CHEMBL427216

GLICLAZIDE
🧪 Phase III
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🧪 Phase III
Cc1ccc(S(=O)(=O)NC(=O)NN2CC3CCCC3C2)cc1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL427216
Name GLICLAZIDE
Phase Phase III
Structure Type MOL
InChI Key BOVGTQGAOIONJV-UHFFFAOYSA-N
Therapeutic ✓ Yes

Known Names

Bilxona Dacadis mr Diaglyk Diamicron Diamicron mr Edicil Gliclazida Gliclazide Glimicron Glimil J3.151H Nazdol mr +10 more
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
20
Publications
22
Known Names
3
Indications
1
Mechanisms

Molecular Properties

323.4
MW (Da)
1.63
ALogP
4
HBA
2
HBD
78.5
PSA (Ų)
0.89
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Racemic

Flags

Natural Product
USAN Stem gli-

Extended Properties

Molecular Formula C15H21N3O3S
MW 323.42
Aromatic Rings 1
Heavy Atoms 22
NP-Likeness -0.87

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Sulfonylurea receptor 1, Kir6.2 blocker BLOCKER Sulfonylurea receptor 1, Kir6.2 ✓ ✓

Indications

Diabetes Mellitus Diabetes Mellitus, Type 2 Epilepsy

ATC Classification

A10BB09
gliclazide
Level 1: ALIMENTARY TRACT AND METABOLISM
Level 2: DRUGS USED IN DIABETES

Activity Summary

IC50 4 meas. best 6.19

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
 IC50 6.19 5.965 640.3 2
Aldo-keto reductase family 1 member C3
CHEMBL4681
 IC50 4.71 4.71 19620.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked IC50 = 640.33 nM 6.19 PubChem BioAssay. tonic K+ channel activity under 0.1 mM glucose conditions in I... -
Unchecked IC50 = 1833.95 nM 5.74 PubChem BioAssay. insulin secretion from INS-1E cells in the presence of 5 mM gl... -
Aldo-keto reductase family 1 member C3 IC50 = 19620.0 nM 4.71 Inhibition of N-terminal His-tagged human AKR1C3 expressed in Escherichia coli B... 32463235

Literature References

PubMed DOI Target Context # Activities
- 10.6019/CHEMBL3885881 Rattus norvegicus 320
- 10.5281/zenodo.13943903 ADMET 89
31158845 10.1038/s41586-019-1291-3 ADMET 74
22194678 10.1371/journal.pcbi.1002310 Hepatotoxicity 14
15646539 10.1016/s0399-8320(04)95062-2 Unchecked 11
15646539 10.1016/s0399-8320(04)95062-2 NON-PROTEIN TARGET 8
18083521 10.1016/j.bmc.2007.11.062 Rattus norvegicus 3
33984475 10.1016/j.bmcl.2021.128096 INS1 3
20014752 10.1021/tx900326k Hepatotoxicity 3
- 10.1007/s00044-012-9970-8 Rattus norvegicus 2
16500101 10.1016/j.bmcl.2006.02.013 Rattus norvegicus 2
19500993 10.1016/j.bmc.2009.05.033 Rattus norvegicus 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
37468498 10.1038/s41467-023-40064-9 Gamma-aminobutyric acid receptor subunit alpha-1 2
37468498 10.1038/s41467-023-40064-9 Mu-type opioid receptor 2
33765605 10.1016/j.ejmech.2021.113325 Unchecked 2
19171410 10.1016/j.ejmech.2008.12.013 Rattus norvegicus 2
36781148 10.1016/j.bmcl.2023.129186 Unchecked 2
18436346 10.1016/j.ejmech.2008.03.009 Rattus norvegicus 2
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M2 2

Data from ChEMBL 36 via Core Engine