Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL1200638

DEXBROMPHENIRAMINE MALEATE
💊 Approved Drug
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
💊 Approved Drug
CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1.O=C(O)/C=C\C(=O)O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1200638
Name DEXBROMPHENIRAMINE MALEATE
Phase Approved
Structure Type MOL
InChI Key SRGKFVAASLQVBO-DASCVMRKSA-N
Therapeutic ✓ Yes
Parent Compound CHEMBL1201287
Active Moiety CHEMBL1201287

Known Names

Brompheniramine d-form maleate Dexbrompheniramine maleate Dexbrompheniramine maleate component of brompheril Dexbrompheniramine maleate component of disobrom Dexbrompheniramine maleate component of disophrol Dexbrompheniramine maleate component of drixoral Dexbrompheniramine maleate component of drixoral plus Dexbrompheniramine maleate component of resporal Disomer
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
11
Publications
9
Known Names
1
Indications
1
Mechanisms

Molecular Properties

319.2
MW (Da)
3.93
ALogP
2
HBA
0
HBD
16.1
PSA (Ų)
0.83
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1963
Availability Discontinued
Chirality Single Enantiomer

Routes of Administration

Oral

Extended Properties

Molecular Formula C20H23BrN2O4
MW 435.32
Aromatic Rings 2
Heavy Atoms 19
NP-Likeness -1.24

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Histamine H1 receptor antagonist ANTAGONIST Histamine H1 receptor ✓ ✓

Indications

Rhinitis, Allergic, Seasonal

Activity Summary

IC50 2 meas. best 5.42

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
 IC50 5.42 5.31 3759.9 2

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked IC50 = 3759.92 nM 5.42 PubChem BioAssay. insulin secretion from INS-1E cells in the presence of 5 mM gl... -
Unchecked IC50 = 6367.81 nM 5.2 PubChem BioAssay. insulin secretion from INS-1E cells in the presence of 0.1 mM ... -

Literature References

PubMed DOI Target Context # Activities
23956101 10.1093/toxsci/kft176 Bile salt export pump 1
23956101 10.1093/toxsci/kft176 ATP-binding cassette sub-family C member 2 1
23956101 10.1093/toxsci/kft176 ATP-binding cassette sub-family C member 3 1
23956101 10.1093/toxsci/kft176 ATP-binding cassette sub-family C member 4 1
- 10.6019/CHEMBL4513141 Candida albicans 1
- 10.6019/CHEMBL4513141 Cryptococcus neoformans 1
- 10.6019/CHEMBL4513141 Escherichia coli 1
- 10.6019/CHEMBL4513141 Klebsiella pneumoniae 1
- 10.6019/CHEMBL4513141 Pseudomonas aeruginosa 1
- 10.6019/CHEMBL4513141 Acinetobacter baumannii 1
- 10.6019/CHEMBL4513141 Staphylococcus aureus 1

Data from ChEMBL 36 via Core Engine