Assay Detail
Binding
CHEMBL839482
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Dissociation constant for inhibition of equine Butyrylcholinesterase (BuChE)
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 8.43 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175949 | — | — | 1 | 9.96 |
| CHEMBL179192 | — | — | 1 | 9.64 |
| CHEMBL129108 | — | — | 1 | 9.40 |
| CHEMBL175555 | — | — | 1 | 9.17 |
| CHEMBL180267 | — | — | 1 | 9.12 |
| CHEMBL262565 | — | — | 1 | 9.03 |
| CHEMBL180581 | — | — | 1 | 8.70 |
| CHEMBL75274 | — | — | 1 | 8.70 |
| CHEMBL32823 | — | — | 1 | 8.70 |
| CHEMBL178050 | — | — | 1 | 8.64 |
| CHEMBL175487 | — | — | 1 | 8.48 |
| CHEMBL367067 | — | — | 1 | 8.38 |
| CHEMBL338755 | — | — | 1 | 8.22 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 8.15 |
| CHEMBL1206 | ETHOPROPAZINE | 4.0 | 1 | 7.70 |
| CHEMBL361766 | — | — | 1 | 7.57 |
| CHEMBL51197 | — | — | 1 | 7.46 |
| CHEMBL179732 | — | — | 1 | 7.00 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175949 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL179192 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL129108 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL175555 | — | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL180267 | — | Ki | = | 0.76 | nM | 9.12 |
| CHEMBL262565 | — | Ki | = | 0.94 | nM | 9.03 |
| CHEMBL180581 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL75274 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL32823 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL178050 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL175487 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL367067 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL338755 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL95 | TACRINE | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL1206 | ETHOPROPAZINE | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL361766 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL51197 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL179732 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL502 | DONEPEZIL | Ki | = | 640.0 | nM | 6.19 |