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Compound Detail

CHEMBL175487

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OCCN(CCCNc1c2c(nc3ccccc13)CCCC2)CCCNc1c2ccccc2nc2ccccc12

Basic Information

ChEMBL ID CHEMBL175487
Phase Preclinical
Structure Type MOL
InChI Key AOGQLQNSBYGTMC-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

533.7
MW (Da)
6.41
ALogP
6
HBA
3
HBD
73.3
PSA (Ų)
0.13
QED
2
Ro5 Violations
12
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C34H39N5O
MW 533.72
Aromatic Rings 5
Heavy Atoms 40
NP-Likeness -0.62

Activity Summary

Ki 2 meas. best 9.19

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Acetylcholinesterase
CHEMBL4768
Ki 9.19 9.19 0.7 1
Butyrylcholinesterase
CHEMBL5077
Ki 8.48 8.48 3.3 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
15771436 10.1021/jm049510k Acetylcholinesterase 1
15771436 10.1021/jm049510k Butyrylcholinesterase 1
15771436 10.1021/jm049510k Unchecked 1

Data from ChEMBL 36 via Core Engine