Assay Detail
Binding
CHEMBL838823
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Dissociation constant for inhibition of fetal bovine serum Acetylcholinesterase
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 7.76 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338755 | — | — | 1 | 10.22 |
| CHEMBL175487 | — | — | 1 | 9.19 |
| CHEMBL32823 | — | — | 1 | 8.89 |
| CHEMBL180267 | — | — | 1 | 8.80 |
| CHEMBL75274 | — | — | 1 | 8.72 |
| CHEMBL262565 | — | — | 1 | 8.55 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 8.54 |
| CHEMBL367067 | — | — | 1 | 8.04 |
| CHEMBL361766 | — | — | 1 | 7.52 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.40 |
| CHEMBL175949 | — | — | 1 | 7.33 |
| CHEMBL179192 | — | — | 1 | 7.30 |
| CHEMBL175555 | — | — | 1 | 6.89 |
| CHEMBL178050 | — | — | 1 | 6.71 |
| CHEMBL179732 | — | — | 1 | 6.68 |
| CHEMBL129108 | — | — | 1 | 6.60 |
| CHEMBL51197 | — | — | 1 | 6.47 |
| CHEMBL180581 | — | — | 1 | 5.82 |
| CHEMBL1206 | ETHOPROPAZINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338755 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL175487 | — | Ki | = | 0.65 | nM | 9.19 |
| CHEMBL32823 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL180267 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL75274 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL262565 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL502 | DONEPEZIL | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL367067 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL361766 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL95 | TACRINE | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL175949 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL179192 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL175555 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL178050 | — | Ki | = | 195.0 | nM | 6.71 |
| CHEMBL179732 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL129108 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL51197 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL180581 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL1206 | ETHOPROPAZINE | Ki | = | 173200.0 | nM | - |