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Assay Detail

CHEMBL1669910

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Inhibition of CYP2D6 after 30 mins by fluorometric assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Cytochrome P450 2D6 (CHEMBL289)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Cytochrome P450 3A4 inhibitory constituents of the wood of Taxus yunnanensis.
Tezuka Y, Morikawa K, Li F, Auw L, Awale S, Nobukawa T, Kadota S.
J Nat Prod (2011) 74 : 102 -105
PubMed 21138310 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.23 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1294 QUINIDINE 4.0 1 8.00
CHEMBL463246 ALPHA-CONIDENDRIN 1 4.75
CHEMBL1668114 TAXIRESINOL 1 4.17
CHEMBL399512 ISOLARICIRESINOL 1 4.01
CHEMBL1668108 1 -
CHEMBL1668109 1 -
CHEMBL1668110 (7R)-7-HYDROXYTAXIRESINOL 1 -
CHEMBL1668111 ISOTAXIRESINOL 1 -
CHEMBL1668112 1 -
CHEMBL1668113 TANEGOOL 1 -
CHEMBL368347 (+)-SECOISOLARICIRESINOL 2.0 1 -
CHEMBL518421 LARICIRESINOL 1 -
CHEMBL1668115 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1294 QUINIDINE IC50 = 10.0 nM 8.00
CHEMBL463246 ALPHA-CONIDENDRIN IC50 = 17700.0 nM 4.75
CHEMBL1668114 TAXIRESINOL IC50 = 68100.0 nM 4.17
CHEMBL399512 ISOLARICIRESINOL IC50 = 97700.0 nM 4.01
CHEMBL1668108 IC50 > 100000.0 nM -
CHEMBL1668109 IC50 - -
CHEMBL1668110 (7R)-7-HYDROXYTAXIRESINOL IC50 - -
CHEMBL1668111 ISOTAXIRESINOL IC50 - -
CHEMBL1668112 IC50 > 100000.0 nM -
CHEMBL1668113 TANEGOOL IC50 - -
CHEMBL368347 (+)-SECOISOLARICIRESINOL IC50 > 100000.0 nM -
CHEMBL518421 LARICIRESINOL IC50 > 100000.0 nM -
CHEMBL1668115 IC50 > 100000.0 nM -