Voltage-dependent L-type calcium channel subunit alpha-1C · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q13936. Use UniProt Q13936 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q13936 as the stable identity anchor, then attach disease evidence before program review.
Voltage-dependent L-type calcium channel subunit alpha-1C
Review this target as Voltage-dependent L-type calcium channel subunit alpha-1C, mapped to UniProt Q13936. Sequence length is 2221 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Voltage-dependent L-type calcium channel subunit alpha-1C as ChEMBL target CHEMBL1940, mapped to UniProt Q13936. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Voltage-dependent L-type calcium channel subunit alpha-1C |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q13936 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Voltage-dependent L-type calcium channel subunit alpha-1C |
| UniProt Accession | Q13936 |
| Component Type | Protein |
| Sequence Length | 2221 aa |
Voltage-dependent L-type calcium channel subunit alpha-1C
Review this target as Voltage-dependent L-type calcium channel subunit alpha-1C, mapped to UniProt Q13936. Sequence length is 2221 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL475534 | 9.6 | Ki | 0.25 | Clinical |
| CHEMBL475534 | 9.59 | Kd | 0.26 | Clinical |
| CHEMBL193 | 9.4 | Kd | 0.4 | Approved |
| CHEMBL159854 | 9.0 | Ki | 1.0 | Preclinical |
| CHEMBL193 | 9.0 | Ki | 1.0 | Approved |
| CHEMBL1648 | 8.66 | IC50 | 2.2 | Approved |
| CHEMBL3392281 | 8.59 | Kd | 2.6 | Preclinical |
| CHEMBL1726 | 8.52 | IC50 | 3.0 | Approved |
| CHEMBL104455 | 8.39 | Ki | 4.11 | Preclinical |
| CHEMBL23692 | 8.3 | Kd | 5.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 104 | 52 | 5.1 |
| cell-based format | 37 | 51 | 5.8 |
| cell membrane format | 8 | 18 | 7.1 |
| assay format | 7 | 27 | 5.8 |
| tissue-based format | 6 | 21 | 6.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 131 | 69 | 5.5 |
| tissue-based format | 1 | 1 | 6.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 13 | 4 | 4.8 |
| cell-based format | 6 | 6 | 5.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 10 | 10 | 4.9 |
| cell-based format | 5 | 1 | 5.8 |
| assay format | 1 | 1 | 4.0 |