Compound Detail
CHEMBL23692
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Basic Information
| ChEMBL ID | CHEMBL23692 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WASSYUHVCUFIGT-VKAVYKQESA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
407.5
MW (Da)
4.89
ALogP
8
HBA
1
HBD
97.3
PSA (Ų)
0.53
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.44
Kd 1 meas. best 8.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Voltage-dependent L-type calcium channel subunit alpha-1C CHEMBL1940 | Kd | 8.3 | 8.3 | 5.0 | 1 |
| Oryctolagus cuniculus CHEMBL374 | IC50 | 7.44 | 7.44 | 36.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Voltage-dependent L-type calcium channel subunit alpha-1C | Kd | = | 5.0 | nM | 8.3 | Displacement of [3H]nitrendipine from dihydropyridine receptor of guinea pig myo... | 7837222 |
| Oryctolagus cuniculus | IC50 | = | 36.0 | nM | 7.44 | In vitro inhibition of potassium-induced contractions in rabbit aorta strips. | 7837222 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 7837222 | 10.1021/jm00001a017 | Oryctolagus cuniculus | 2 |
| 7837222 | 10.1021/jm00001a017 | Voltage-dependent L-type calcium channel subunit alpha-1C | 1 |
Data from ChEMBL 36 via Core Engine