Assay Detail
Functional
CHEMBL772775
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In vitro inhibition of potassium-induced contractions in rabbit aorta strips.
20
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Calcium entry blockers and activators: conformational and structural determinants of dihydropyrimidine calcium channel modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.75 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | 7.72 |
| CHEMBL23692 | — | — | 1 | 7.44 |
| CHEMBL282706 | — | — | 3 | 7.00 |
| CHEMBL280926 | — | — | 1 | 5.75 |
| CHEMBL23386 | — | — | 1 | 5.64 |
| CHEMBL282279 | — | — | 1 | 5.60 |
| CHEMBL283013 | — | — | 1 | 4.77 |
| CHEMBL23451 | — | — | 1 | 4.70 |
| CHEMBL279029 | — | — | 1 | 4.69 |
| CHEMBL25763 | — | — | 1 | 4.58 |
| CHEMBL24491 | — | — | 1 | - |
| CHEMBL284266 | — | — | 1 | - |
| CHEMBL22704 | — | — | 3 | - |
| CHEMBL23720 | — | — | 1 | - |
| CHEMBL22705 | — | — | 1 | - |
| CHEMBL23642 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193 | NIFEDIPINE | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL23692 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL282706 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL280926 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL23386 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL282279 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL282706 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL283013 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL23451 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL279029 | — | IC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL25763 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL22704 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL24491 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL23642 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL22704 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL22705 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL282706 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL23720 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL22704 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL284266 | — | IC50 | > | 30000.0 | nM | - |