Assay Detail
Functional
CHEMBL4392004
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Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 harboring V259L mutant infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.79 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 8.39 |
| CHEMBL4436307 | — | — | 1 | 8.26 |
| CHEMBL38827 | LUMEFANTRINE | 4.0 | 1 | 8.19 |
| CHEMBL303933 | PIPERAQUINE | 3.0 | 1 | 8.15 |
| CHEMBL3261733 | — | — | 1 | 7.96 |
| CHEMBL7568 | QUINACRINE | 4.0 | 1 | 7.75 |
| CHEMBL172 | (S,R)-MEFLOQUINE | — | 1 | 7.64 |
| CHEMBL4457749 | — | — | 1 | 6.85 |
| CHEMBL4457910 | — | — | 1 | 6.67 |
| CHEMBL170 | QUININE | 4.0 | 1 | 6.67 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.58 |
| CHEMBL4544761 | — | — | 1 | 6.45 |
| CHEMBL4529933 | — | — | 1 | 6.28 |
| CHEMBL4451413 | — | — | 1 | 6.26 |
| CHEMBL4579700 | — | — | 1 | 6.17 |
| CHEMBL4571858 | — | — | 1 | 5.96 |
| CHEMBL4573274 | — | — | 1 | 5.88 |
| CHEMBL4544660 | — | — | 1 | 5.84 |
| CHEMBL4547527 | — | — | 1 | 5.67 |
| CHEMBL4562828 | — | — | 1 | 5.51 |
| CHEMBL4469013 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1450 | ATOVAQUONE | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL4436307 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL38827 | LUMEFANTRINE | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL303933 | PIPERAQUINE | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL3261733 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL7568 | QUINACRINE | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL172 | (S,R)-MEFLOQUINE | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4457749 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4457910 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL170 | QUININE | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4544761 | — | IC50 | = | 355.0 | nM | 6.45 |
| CHEMBL4529933 | — | IC50 | = | 525.0 | nM | 6.28 |
| CHEMBL4451413 | — | IC50 | = | 551.0 | nM | 6.26 |
| CHEMBL4579700 | — | IC50 | = | 668.0 | nM | 6.17 |
| CHEMBL4571858 | — | IC50 | = | 1103.0 | nM | 5.96 |
| CHEMBL4573274 | — | IC50 | = | 1321.0 | nM | 5.88 |
| CHEMBL4544660 | — | IC50 | = | 1439.0 | nM | 5.84 |
| CHEMBL4547527 | — | IC50 | = | 2122.0 | nM | 5.67 |
| CHEMBL4562828 | — | IC50 | = | 3113.0 | nM | 5.51 |
| CHEMBL4469013 | — | IC50 | = | 3070.0 | nM | 5.51 |