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Target Snapshot

CHEMBL612889 Target Snapshot

Plasmodium yoelii · ORGANISM · Plasmodium yoelii

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5,095Compounds
351Assays
10Approved Drugs
593.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Plasmodium yoelii as ChEMBL target CHEMBL612889. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Plasmodium yoelii
ORGANISM · Plasmodium yoelii
As of 2026-09-13
ChEMBL target ID
CHEMBL612889
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NamePlasmodium yoelii
Target TypeORGANISM
OrganismPlasmodium yoelii
ChEMBL ↗ NCBI Taxonomy ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelPlasmodium yoelii
UniProt AccessionN/A

Plasmodium yoelii

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Plasmodium yoelii.

Review namePlasmodium yoelii
OrganismPlasmodium yoelii
Clinical Profile

Clinical Phase Distribution

10
Approved
5
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50582.0
EC5011.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL416230 9.75 IC50 0.177 Clinical
CHEMBL4091762 9.0 EC50 1.0 Clinical
CHEMBL4764214 9.0 EC50 1.0 Preclinical
CHEMBL578967 8.73 IC50 1.85 Preclinical
CHEMBL36 8.67 IC50 2.152 Approved
CHEMBL600754 8.64 IC50 2.286 Preclinical
CHEMBL416230 8.59 EC50 2.6 Clinical
CHEMBL544227 8.59 IC50 2.56 Preclinical
CHEMBL4783407 8.4 EC50 4.0 Preclinical
CHEMBL581449 8.38 IC50 4.18 Preclinical
Distribution

pChEMBL Value Distribution

29
5.0
36
5.5
66
6.0
83
6.5
56
7.0
29
7.5
15
8.0
5
8.5
3
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

ATOVAQUONE
CHEMBL1450
Approved 1992
Properties Compare Identifier
PYRIMETHAMINE
CHEMBL36
Approved 1953
Properties Compare Identifier
PRIMAQUINE
CHEMBL506
Approved 1952
Properties Compare Identifier
CHLOROQUINE
CHEMBL76
Approved 1949
Properties Compare Identifier
EMETINE
CHEMBL50588
Properties Compare Identifier
QUINACRINE
CHEMBL7568
Properties Compare Identifier
DEQUALINIUM CHLORIDE
CHEMBL121663
Properties Compare Identifier
Assay Landscape

Assay Landscape

357
Total Assays
323
Tested Compounds
1
Assay Types
Functional — 357 assays, 323 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 355 323 6.6
assay format 2 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine