Assay Detail
Functional
CHEMBL1040692
Review assay metadata, readout intent, target linkage, and publication context from the same page.
NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay
5697
Total Activities
5614
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5697 | 6.39 | 8.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL585665 | — | — | 1 | 8.90 |
| CHEMBL531809 | — | — | 1 | 8.82 |
| CHEMBL588690 | — | — | 1 | 8.79 |
| CHEMBL2310931 | — | — | 1 | 8.75 |
| CHEMBL580164 | — | — | 1 | 8.75 |
| CHEMBL602176 | — | — | 1 | 8.71 |
| CHEMBL499519 | NOCARDIMICIN B | — | 1 | 8.65 |
| CHEMBL1606 | — | — | 1 | 8.62 |
| CHEMBL578924 | — | — | 1 | 8.61 |
| CHEMBL602389 | — | — | 1 | 8.50 |
| CHEMBL596653 | — | — | 1 | 8.50 |
| CHEMBL600715 | — | — | 1 | 8.48 |
| CHEMBL578273 | — | — | 1 | 8.48 |
| CHEMBL600913 | — | — | 1 | 8.45 |
| CHEMBL533376 | — | — | 1 | 8.44 |
| CHEMBL577200 | — | — | 1 | 8.41 |
| CHEMBL591861 | — | — | 1 | 8.39 |
| CHEMBL578706 | — | — | 1 | 8.38 |
| CHEMBL581886 | CEPHAELINE HYDROBROMIDE | — | 1 | 8.37 |
| CHEMBL600942 | — | — | 1 | 8.36 |
| CHEMBL580137 | — | — | 1 | 8.34 |
| CHEMBL345083 | — | — | 1 | 8.34 |
| CHEMBL601754 | — | — | 1 | 8.34 |
| CHEMBL579341 | — | — | 1 | 8.32 |
| CHEMBL579905 | — | — | 1 | 8.32 |
| CHEMBL580144 | — | — | 1 | 8.30 |
| CHEMBL583119 | — | — | 1 | 8.28 |
| CHEMBL579338 | — | — | 1 | 8.27 |
| CHEMBL578948 | — | — | 1 | 8.26 |
| CHEMBL317364 | — | — | 1 | 8.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL585665 | — | EC50 | = | 1.258 | nM | 8.90 |
| CHEMBL531809 | — | EC50 | = | 1.501 | nM | 8.82 |
| CHEMBL588690 | — | EC50 | = | 1.614 | nM | 8.79 |
| CHEMBL580164 | — | EC50 | = | 1.772 | nM | 8.75 |
| CHEMBL2310931 | — | EC50 | = | 1.779 | nM | 8.75 |
| CHEMBL602176 | — | EC50 | = | 1.926 | nM | 8.71 |
| CHEMBL499519 | NOCARDIMICIN B | EC50 | = | 2.241 | nM | 8.65 |
| CHEMBL1606 | — | EC50 | = | 2.372 | nM | 8.62 |
| CHEMBL578924 | — | EC50 | = | 2.45 | nM | 8.61 |
| CHEMBL602389 | — | EC50 | = | 3.19 | nM | 8.50 |
| CHEMBL596653 | — | EC50 | = | 3.141 | nM | 8.50 |
| CHEMBL578273 | — | EC50 | = | 3.29 | nM | 8.48 |
| CHEMBL600715 | — | EC50 | = | 3.31 | nM | 8.48 |
| CHEMBL600913 | — | EC50 | = | 3.55 | nM | 8.45 |
| CHEMBL533376 | — | EC50 | = | 3.62 | nM | 8.44 |
| CHEMBL577200 | — | EC50 | = | 3.91 | nM | 8.41 |
| CHEMBL591861 | — | EC50 | = | 4.11 | nM | 8.39 |
| CHEMBL578706 | — | EC50 | = | 4.14 | nM | 8.38 |
| CHEMBL581886 | CEPHAELINE HYDROBROMIDE | EC50 | = | 4.23 | nM | 8.37 |
| CHEMBL600942 | — | EC50 | = | 4.36 | nM | 8.36 |
| CHEMBL345083 | — | EC50 | = | 4.58 | nM | 8.34 |
| CHEMBL580137 | — | EC50 | = | 4.57 | nM | 8.34 |
| CHEMBL601754 | — | EC50 | = | 4.56 | nM | 8.34 |
| CHEMBL579905 | — | EC50 | = | 4.81 | nM | 8.32 |
| CHEMBL579341 | — | EC50 | = | 4.81 | nM | 8.32 |
| CHEMBL580144 | — | EC50 | = | 4.95 | nM | 8.30 |
| CHEMBL583119 | — | EC50 | = | 5.28 | nM | 8.28 |
| CHEMBL579338 | — | EC50 | = | 5.41 | nM | 8.27 |
| CHEMBL578948 | — | EC50 | = | 5.52 | nM | 8.26 |
| CHEMBL317364 | — | EC50 | = | 6.01 | nM | 8.22 |
| CHEMBL602164 | — | EC50 | = | 6.21 | nM | 8.21 |
| CHEMBL582646 | — | EC50 | = | 6.15 | nM | 8.21 |
| CHEMBL579155 | — | EC50 | = | 6.28 | nM | 8.20 |
| CHEMBL586448 | — | EC50 | = | 6.35 | nM | 8.20 |
| CHEMBL579279 | — | EC50 | = | 6.53 | nM | 8.19 |
| CHEMBL576205 | — | EC50 | = | 6.85 | nM | 8.16 |
| CHEMBL307261 | ARTENIMOL | EC50 | = | 7.1 | nM | 8.15 |
| CHEMBL531150 | — | EC50 | = | 7.23 | nM | 8.14 |
| CHEMBL578919 | — | EC50 | = | 7.38 | nM | 8.13 |
| CHEMBL600530 | — | EC50 | = | 7.51 | nM | 8.12 |
| CHEMBL578735 | — | EC50 | = | 7.62 | nM | 8.12 |
| CHEMBL603009 | — | EC50 | = | 7.84 | nM | 8.11 |
| CHEMBL604517 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL416956 | MEFLOQUINE | EC50 | = | 8.14 | nM | 8.09 |
| CHEMBL586407 | — | EC50 | = | 8.39 | nM | 8.08 |
| CHEMBL578284 | — | EC50 | = | 8.49 | nM | 8.07 |
| CHEMBL535079 | — | EC50 | = | 8.44 | nM | 8.07 |
| CHEMBL578283 | — | EC50 | = | 8.74 | nM | 8.06 |
| CHEMBL601190 | — | EC50 | = | 8.7 | nM | 8.06 |
| CHEMBL585399 | — | EC50 | = | 9.13 | nM | 8.04 |