Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL5348491

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimalarial activity against blood stage Plasmodium falciparum 3D7 assessed as reduction in parasite growth incubated for 72 hrs by SYBR Green dye based fluorescence assay
ChEMBL ↗
51
Total Activities
51
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364) ↗
Type ORGANISM
Organism Plasmodium falciparum

Publication

Discovery of potent Plasmodium falciparum protein kinase 6 (PfPK6) inhibitors with a type II inhibitor pharmacophore.
Ong HW, Truong A, Kwarcinski F, de Silva C, Avalani K, Havener TM, Chirgwin M, Galal KA, Willis C, Krämer A, Liu S, Knapp S, Derbyshire ER, Zutshi R, Drewry DH.
Eur J Med Chem (2023) 249 : 115043 -115043
PubMed 36736152 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 37 6.68 9.85
Activity 14 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL307261 ARTENIMOL 3.0 1 9.85
CHEMBL36 PYRIMETHAMINE 4.0 1 7.57
CHEMBL7568 QUINACRINE 4.0 1 7.48
CHEMBL5402319 — — 1 7.41
CHEMBL5404309 — — 1 7.40
CHEMBL5407751 — — 1 7.12
CHEMBL5440849 — — 1 7.09
CHEMBL5414544 — — 1 7.08
CHEMBL5438744 — — 1 7.08
CHEMBL5414363 — — 1 6.96
CHEMBL5397928 — — 1 6.85
CHEMBL5405119 — — 1 6.82
CHEMBL5417668 — — 1 6.80
CHEMBL5400583 — — 1 6.64
CHEMBL5405690 — — 1 6.60
CHEMBL5420882 — — 1 6.60
CHEMBL5429163 — — 1 6.57
CHEMBL5404242 — — 1 6.57
CHEMBL5407060 — — 1 6.52
CHEMBL5421495 — — 1 6.51
CHEMBL5400679 — — 1 6.50
CHEMBL5428638 — — 1 6.48
CHEMBL5405467 — — 1 6.48
CHEMBL5399124 — — 1 6.48
CHEMBL5395335 — — 1 6.41
CHEMBL5420399 — — 1 6.39
CHEMBL5418962 — — 1 6.39
CHEMBL5417033 — — 1 6.31
CHEMBL247228 GW770249X — 1 6.30
CHEMBL5398147 — — 1 6.27

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL307261 ARTENIMOL EC50 = 0.14 nM 9.85
CHEMBL36 PYRIMETHAMINE EC50 = 27.0 nM 7.57
CHEMBL7568 QUINACRINE EC50 = 33.0 nM 7.48
CHEMBL5402319 — EC50 = 39.0 nM 7.41
CHEMBL5404309 — EC50 = 40.0 nM 7.40
CHEMBL5407751 — EC50 = 75.0 nM 7.12
CHEMBL5440849 — EC50 = 82.0 nM 7.09
CHEMBL5414544 — EC50 = 84.0 nM 7.08
CHEMBL5438744 — EC50 = 83.0 nM 7.08
CHEMBL5414363 — EC50 = 110.0 nM 6.96
CHEMBL5397928 — EC50 = 140.0 nM 6.85
CHEMBL5405119 — EC50 = 150.0 nM 6.82
CHEMBL5417668 — EC50 = 160.0 nM 6.80
CHEMBL5400583 — EC50 = 230.0 nM 6.64
CHEMBL5420882 — EC50 = 250.0 nM 6.60
CHEMBL5405690 — EC50 = 250.0 nM 6.60
CHEMBL5429163 — EC50 = 270.0 nM 6.57
CHEMBL5404242 — EC50 = 270.0 nM 6.57
CHEMBL5407060 — EC50 = 300.0 nM 6.52
CHEMBL5421495 — EC50 = 310.0 nM 6.51
CHEMBL5400679 — EC50 = 320.0 nM 6.50
CHEMBL5428638 — EC50 = 330.0 nM 6.48
CHEMBL5405467 — EC50 = 330.0 nM 6.48
CHEMBL5399124 — EC50 = 330.0 nM 6.48
CHEMBL5395335 — EC50 = 390.0 nM 6.41
CHEMBL5420399 — EC50 = 410.0 nM 6.39
CHEMBL5418962 — EC50 = 410.0 nM 6.39
CHEMBL5417033 — EC50 = 490.0 nM 6.31
CHEMBL247228 GW770249X EC50 = 500.0 nM 6.30
CHEMBL5398147 — EC50 = 540.0 nM 6.27
CHEMBL5414579 — EC50 = 580.0 nM 6.24
CHEMBL5398326 — EC50 = 630.0 nM 6.20
CHEMBL5416069 — EC50 = 660.0 nM 6.18
CHEMBL5438128 — EC50 = 800.0 nM 6.10
CHEMBL5426653 — EC50 = 2190.0 nM 5.66
CHEMBL5435130 — EC50 = 2520.0 nM 5.60
CHEMBL5419731 — EC50 = 3010.0 nM 5.52
CHEMBL5433238 — Activity - — -
CHEMBL5396897 — Activity - — -
CHEMBL5427384 — Activity - — -
CHEMBL5435885 — Activity - — -
CHEMBL5395319 — Activity - — -
CHEMBL5398401 — Activity - — -
CHEMBL5426500 — Activity - — -
CHEMBL178455 — Activity - — -
CHEMBL5420208 — Activity - — -
CHEMBL5430742 — Activity - — -
CHEMBL5425086 — Activity - — -
CHEMBL5408596 — Activity - — -
CHEMBL5413903 — Activity - — -