Assay Detail
Functional
CHEMBL3055250
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Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pharmacophore-based predictive model generation for potent antimalarials targeting haem detoxification pathway
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.51 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1213257 | AMOPYROQUINE | 2.0 | 1 | 8.28 |
| CHEMBL316098 | N-TERT-BUTYL-AMODIAQUINE | — | 1 | 8.26 |
| CHEMBL35228 | PYRONARIDINE | 3.0 | 1 | 8.24 |
| CHEMBL1107 | HALOFANTRINE | 4.0 | 1 | 8.24 |
| CHEMBL1235 | DESETHYL AMODIAQUINE | — | 1 | 8.16 |
| CHEMBL1630 | — | — | 1 | 8.11 |
| CHEMBL343770 | TEBAQUINE | — | 1 | 8.02 |
| CHEMBL7568 | QUINACRINE | 4.0 | 1 | 7.89 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.85 |
| CHEMBL448594 | Chloroquine-pyrolidinyl | — | 1 | 7.72 |
| CHEMBL1236 | DESETHYLCHLOROQUINE | — | 1 | 7.72 |
| CHEMBL1631 | BIDESETHYL AMODIAQUINE | — | 1 | 7.68 |
| CHEMBL588619 | CINCHONINE | -1.0 | 1 | 7.68 |
| CHEMBL1294 | QUINIDINE | 4.0 | 1 | 7.68 |
| CHEMBL172 | (S,R)-MEFLOQUINE | — | 1 | 7.64 |
| CHEMBL170 | QUININE | 4.0 | 1 | 7.47 |
| CHEMBL533841 | CINCHONIDINE | -1.0 | 1 | 7.40 |
| CHEMBL510457 | DEHYDROXY TEBAQUINE | — | 1 | 7.38 |
| CHEMBL1656 | BIDESETHYL CHLOROQUINE | — | 1 | 7.26 |
| CHEMBL2263229 | DEHYDROXYFLUORO TEBAQUINE | — | 1 | 7.21 |
| CHEMBL468610 | — | — | 1 | 6.17 |
| CHEMBL375673 | — | — | 1 | 5.85 |
| CHEMBL217786 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1213257 | AMOPYROQUINE | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL316098 | N-TERT-BUTYL-AMODIAQUINE | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL35228 | PYRONARIDINE | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL1107 | HALOFANTRINE | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL1235 | DESETHYL AMODIAQUINE | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL1630 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL343770 | TEBAQUINE | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL7568 | QUINACRINE | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL448594 | Chloroquine-pyrolidinyl | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1236 | DESETHYLCHLOROQUINE | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1631 | BIDESETHYL AMODIAQUINE | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL588619 | CINCHONINE | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1294 | QUINIDINE | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL172 | (S,R)-MEFLOQUINE | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL170 | QUININE | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL533841 | CINCHONIDINE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL510457 | DEHYDROXY TEBAQUINE | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1656 | BIDESETHYL CHLOROQUINE | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL2263229 | DEHYDROXYFLUORO TEBAQUINE | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL468610 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL375673 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL217786 | — | IC50 | = | 12000.0 | nM | 4.92 |