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Assay Detail

CHEMBL833852

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Effective concentration for Plasmodium falciparum 3D7
14
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Intermediate

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities.
Madrid PB, Sherrill J, Liou AP, Weisman JL, Derisi JL, Guy RK.
Bioorg Med Chem Lett (2005) 15 : 1015 -1018
PubMed 15686903 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 14 7.58 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL144037 1 8.70
CHEMBL7568 QUINACRINE 4.0 2 8.30
CHEMBL182196 1 8.05
CHEMBL76 CHLOROQUINE 4.0 1 7.77
CHEMBL178200 1 7.50
CHEMBL148021 1 7.48
CHEMBL178208 1 7.47
CHEMBL180709 1 7.29
CHEMBL359757 1 7.21
CHEMBL144539 1 7.21
CHEMBL178821 1 7.09
CHEMBL181177 1 7.05
CHEMBL180671 1 6.94

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL144037 EC50 = 2.0 nM 8.70
CHEMBL7568 QUINACRINE EC50 = 5.0 nM 8.30
CHEMBL7568 QUINACRINE EC50 = 8.0 nM 8.10
CHEMBL182196 EC50 = 9.0 nM 8.05
CHEMBL76 CHLOROQUINE EC50 = 17.0 nM 7.77
CHEMBL178200 EC50 = 32.0 nM 7.50
CHEMBL148021 EC50 = 33.0 nM 7.48
CHEMBL178208 EC50 = 34.0 nM 7.47
CHEMBL180709 EC50 = 51.0 nM 7.29
CHEMBL359757 EC50 = 62.0 nM 7.21
CHEMBL144539 EC50 = 62.0 nM 7.21
CHEMBL178821 EC50 = 82.0 nM 7.09
CHEMBL181177 EC50 = 90.0 nM 7.05
CHEMBL180671 EC50 = 115.0 nM 6.94