Compound Detail
CHEMBL1200848
HYDROXYPROGESTERONE CAPROATE 💊 Approved Drug
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💊 Approved Drug
CCCCCC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C
Basic Information
| ChEMBL ID | CHEMBL1200848 |
| Name | HYDROXYPROGESTERONE CAPROATE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | DOMWKUIIPQCAJU-LJHIYBGHSA-N |
| Therapeutic | ✓ Yes |
2
Targets
2
Activities
2
Assay Types
2
PK Parameters
20
Publications
29
Known Names
2
Indications
1
Mechanisms
Molecular Properties
428.6
MW (Da)
5.97
ALogP
4
HBA
0
HBD
60.4
PSA (Ų)
0.39
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1975 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Progesterone receptor agonist | AGONIST | Progesterone receptor | ✓ | ✓ |
Indications
Premature Birth Pregnancy
ATC Classification
G03DA03
hydroxyprogesterone
Level 1: GENITO URINARY SYSTEM AND SEX HORMONES
Level 2: SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
Drug Warnings
Withdrawn
carcinogenicity
possible but unconfirmed risk of cancer
Withdrawn
carcinogenicity
increased risk of cancer in offspring exposed to 17-OHPC in utero
Activity Summary
EC50 1 meas. best 5.31
IC50 1 meas. best 5.2
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein RecA CHEMBL1741171 | EC50 | 5.31 | 5.31 | 4880.0 | 1 |
| SARS-CoV-2 CHEMBL4303835 | IC50 | 5.2 | 5.2 | 6300.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| Cmax | 20.0 | nM | Homo sapiens |
| Cmax | 70.0 | nM | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein RecA | EC50 | = | 4880.0 | nM | 5.31 | PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inh... | - |
| SARS-CoV-2 | IC50 | = | 6300.0 | nM | 5.2 | Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in ... | - |
Literature References
Data from ChEMBL 36 via Core Engine