Compound Detail
CHEMBL2355051
CLOMIPHENE 💊 Approved Drug
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL2355051 |
| Name | CLOMIPHENE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | GKIRPKYJQBWNGO-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
8
Targets
10
Activities
3
Assay Types
0
PK Parameters
20
Publications
3
Known Names
3
Indications
Molecular Properties
406.0
MW (Da)
6.56
ALogP
2
HBA
0
HBD
12.5
PSA (Ų)
0.37
QED
1
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1967 |
| Availability | Prescription |
| Chirality | Achiral |
Indications
Hypogonadism Hypogonadism Anovulation
ATC Classification
G03GB02
clomifene
Level 1: GENITO URINARY SYSTEM AND SEX HORMONES
Level 2: SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
Activity Summary
IC50 7 meas. best 6.66
EC50 2 meas. best 4.91
Ki 1 meas. best 5.71
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium berghei CHEMBL612653 | IC50 | 6.66 | 6.66 | 219.0 | 1 |
| 5-hydroxytryptamine receptor 6 CHEMBL3371 | Ki | 5.71 | 5.71 | 1956.0 | 1 |
| NACHT, LRR and PYD domains-containing protein 3 CHEMBL1741208 | IC50 | 5.62 | 5.075 | 2410.0 | 2 |
| Unchecked CHEMBL612545 | IC50 | 5.36 | 5.36 | 4351.6 | 1 |
| SARS-CoV-2 CHEMBL4303835 | IC50 | 5.27 | 5.27 | 5360.0 | 1 |
| HepG2 CHEMBL395 | IC50 | 4.96 | 4.96 | 11000.0 | 1 |
| Protein RecA CHEMBL1741171 | EC50 | 4.91 | 4.91 | 12400.0 | 1 |
| Androgen receptor CHEMBL3072 | IC50 | 4.87 | 4.87 | 13489.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine