Assay Detail
Functional
CHEMBL2092592
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HARVARD: Inhibition of liver stage Plasmodium berghei infection in HepG2 cells
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium berghei |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Liver-stage malaria parasites vulnerable to diverse chemical scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 6.84 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 9.52 |
| CHEMBL1353042 | OLIGOMYCIN C | — | 1 | 9.30 |
| CHEMBL5314365 | MONENSIN SODIUM | 4.0 | 1 | 9.22 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 8.78 |
| CHEMBL1077120 | SALINOMYCIN SODIUM | — | 1 | 8.70 |
| CHEMBL211501 | ANTIMYCIN A | — | 1 | 8.64 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 8.33 |
| CHEMBL416230 | DECOQUINATE | 2.0 | 1 | 8.27 |
| CHEMBL1489769 | LASALOCID A SODIUM | — | 1 | 7.96 |
| CHEMBL522502 | — | — | 1 | 7.92 |
| CHEMBL1017 | TELMISARTAN | 4.0 | 1 | 7.60 |
| CHEMBL123292 | CYCLOHEXIMIDE | 2.0 | 1 | 7.33 |
| CHEMBL493439 | EMETINE HYDROCHLORIDE | 2.0 | 1 | 7.10 |
| CHEMBL1366 | AURANOFIN | 4.0 | 1 | 6.97 |
| CHEMBL296419 | ASTEMIZOLE | 4.0 | 1 | 6.94 |
| CHEMBL2355051 | CLOMIPHENE | 4.0 | 1 | 6.66 |
| CHEMBL1475252 | TENATOPRAZOLE | 2.0 | 1 | 6.65 |
| CHEMBL2105642 | ESOMEPRAZOLE POTASSIUM | -1.0 | 1 | 6.54 |
| CHEMBL1065 | METHYSERGIDE | 4.0 | 1 | 6.45 |
| CHEMBL261720 | — | — | 1 | 6.33 |
| CHEMBL1503 | OMEPRAZOLE | 4.0 | 1 | 6.17 |
| CHEMBL465226 | GEDUNIN | — | 1 | 6.12 |
| CHEMBL1237054 | PLICAMYCIN | 4.0 | 1 | 6.08 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.05 |
| CHEMBL1200795 | CLEMASTINE FUMARATE | 4.0 | 1 | 6.02 |
| CHEMBL866 | MYCOPHENOLIC ACID | 4.0 | 1 | 6.00 |
| CHEMBL242580 | CICLOPIROX OLAMINE | 3.0 | 1 | 5.98 |
| CHEMBL574915 | LYCORINE HYDROCHLORIDE | — | 1 | 5.91 |
| CHEMBL1256709 | KETANSERIN TARTRATE | — | 1 | 5.87 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1450 | ATOVAQUONE | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL1353042 | OLIGOMYCIN C | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5314365 | MONENSIN SODIUM | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 1.65 | nM | 8.78 |
| CHEMBL1077120 | SALINOMYCIN SODIUM | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL211501 | ANTIMYCIN A | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL416230 | DECOQUINATE | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL1489769 | LASALOCID A SODIUM | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL522502 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1017 | TELMISARTAN | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL123292 | CYCLOHEXIMIDE | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL493439 | EMETINE HYDROCHLORIDE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1366 | AURANOFIN | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL296419 | ASTEMIZOLE | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL2355051 | CLOMIPHENE | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL1475252 | TENATOPRAZOLE | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL2105642 | ESOMEPRAZOLE POTASSIUM | IC50 | = | 291.0 | nM | 6.54 |
| CHEMBL1065 | METHYSERGIDE | IC50 | = | 356.0 | nM | 6.45 |
| CHEMBL261720 | — | IC50 | = | 472.0 | nM | 6.33 |
| CHEMBL1503 | OMEPRAZOLE | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL465226 | GEDUNIN | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL1237054 | PLICAMYCIN | IC50 | = | 833.0 | nM | 6.08 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 886.0 | nM | 6.05 |
| CHEMBL1200795 | CLEMASTINE FUMARATE | IC50 | = | 951.0 | nM | 6.02 |
| CHEMBL866 | MYCOPHENOLIC ACID | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL242580 | CICLOPIROX OLAMINE | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL574915 | LYCORINE HYDROCHLORIDE | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL1256709 | KETANSERIN TARTRATE | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL121663 | DEQUALINIUM CHLORIDE | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL1410 | NONOXYNOL 9 | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL347036 | PROADIFEN HYDROCHLORIDE | IC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 2990.0 | nM | 5.52 |
| CHEMBL1117 | IDARUBICIN | IC50 | = | 6620.0 | nM | 5.18 |
| CHEMBL43128 | PRIMAQUINE PHOSPHATE | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL28079 | ZAPRINAST | IC50 | = | 7790.0 | nM | 5.11 |