Assay Detail
Toxicity
CHEMBL2092591
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HARVARD: Cytotoxicity in HepG2 cell line
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Liver-stage malaria parasites vulnerable to diverse chemical scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 4.72 | 5.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1366 | AURANOFIN | 4.0 | 1 | 5.25 |
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | 5.04 |
| CHEMBL493439 | EMETINE HYDROCHLORIDE | 2.0 | 1 | 5.00 |
| CHEMBL2355051 | CLOMIPHENE | 4.0 | 1 | 4.96 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 4.96 |
| CHEMBL296419 | ASTEMIZOLE | 4.0 | 1 | 4.92 |
| CHEMBL1117 | IDARUBICIN | 4.0 | 1 | 4.91 |
| CHEMBL1353042 | OLIGOMYCIN C | — | 1 | 4.82 |
| CHEMBL9470 | SHIKONIN | — | 1 | 4.55 |
| CHEMBL347036 | PROADIFEN HYDROCHLORIDE | -1.0 | 1 | 4.24 |
| CHEMBL1077120 | SALINOMYCIN SODIUM | — | 1 | 4.24 |
| CHEMBL522502 | — | — | 1 | 4.23 |
| CHEMBL1410 | NONOXYNOL 9 | 4.0 | 1 | 4.21 |
| CHEMBL1200795 | CLEMASTINE FUMARATE | 4.0 | 1 | - |
| CHEMBL211501 | ANTIMYCIN A | — | 1 | - |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | - |
| CHEMBL1017 | TELMISARTAN | 4.0 | 1 | - |
| CHEMBL1065 | METHYSERGIDE | 4.0 | 1 | - |
| CHEMBL123292 | CYCLOHEXIMIDE | 2.0 | 1 | - |
| CHEMBL242580 | CICLOPIROX OLAMINE | 3.0 | 1 | - |
| CHEMBL261720 | — | — | 1 | - |
| CHEMBL121663 | DEQUALINIUM CHLORIDE | 4.0 | 1 | - |
| CHEMBL43128 | PRIMAQUINE PHOSPHATE | 4.0 | 1 | - |
| CHEMBL2105642 | ESOMEPRAZOLE POTASSIUM | -1.0 | 1 | - |
| CHEMBL1256709 | KETANSERIN TARTRATE | — | 1 | - |
| CHEMBL1489769 | LASALOCID A SODIUM | — | 1 | - |
| CHEMBL574915 | LYCORINE HYDROCHLORIDE | — | 1 | - |
| CHEMBL465226 | GEDUNIN | — | 1 | - |
| CHEMBL5314365 | MONENSIN SODIUM | 4.0 | 1 | - |
| CHEMBL866 | MYCOPHENOLIC ACID | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1366 | AURANOFIN | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 9120.0 | nM | 5.04 |
| CHEMBL493439 | EMETINE HYDROCHLORIDE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2355051 | CLOMIPHENE | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL296419 | ASTEMIZOLE | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1117 | IDARUBICIN | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL1353042 | OLIGOMYCIN C | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 28100.0 | nM | 4.55 |
| CHEMBL1077120 | SALINOMYCIN SODIUM | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL347036 | PROADIFEN HYDROCHLORIDE | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL522502 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL1410 | NONOXYNOL 9 | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL1475252 | TENATOPRAZOLE | IC50 | > | 10000.0 | nM | - |
| CHEMBL1237054 | PLICAMYCIN | IC50 | > | 10000.0 | nM | - |
| CHEMBL416230 | DECOQUINATE | IC50 | > | 100000.0 | nM | - |
| CHEMBL1450 | ATOVAQUONE | IC50 | > | 10000.0 | nM | - |
| CHEMBL160 | CYCLOSPORINE | IC50 | > | 50000.0 | nM | - |
| CHEMBL1503 | OMEPRAZOLE | IC50 | > | 10000.0 | nM | - |
| CHEMBL28079 | ZAPRINAST | IC50 | > | 10000.0 | nM | - |
| CHEMBL1200795 | CLEMASTINE FUMARATE | IC50 | > | 50000.0 | nM | - |
| CHEMBL211501 | ANTIMYCIN A | IC50 | > | 100000.0 | nM | - |
| CHEMBL36 | PYRIMETHAMINE | IC50 | > | 10000.0 | nM | - |
| CHEMBL1017 | TELMISARTAN | IC50 | > | 10000.0 | nM | - |
| CHEMBL1065 | METHYSERGIDE | IC50 | > | 10000.0 | nM | - |
| CHEMBL123292 | CYCLOHEXIMIDE | IC50 | > | 100000.0 | nM | - |
| CHEMBL242580 | CICLOPIROX OLAMINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL261720 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL121663 | DEQUALINIUM CHLORIDE | IC50 | > | 100000.0 | nM | - |
| CHEMBL43128 | PRIMAQUINE PHOSPHATE | IC50 | > | 100000.0 | nM | - |
| CHEMBL2105642 | ESOMEPRAZOLE POTASSIUM | IC50 | > | 10000.0 | nM | - |
| CHEMBL1256709 | KETANSERIN TARTRATE | IC50 | > | 100000.0 | nM | - |
| CHEMBL1489769 | LASALOCID A SODIUM | IC50 | > | 100000.0 | nM | - |
| CHEMBL574915 | LYCORINE HYDROCHLORIDE | IC50 | > | 100000.0 | nM | - |
| CHEMBL465226 | GEDUNIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL5314365 | MONENSIN SODIUM | IC50 | > | 100000.0 | nM | - |
| CHEMBL866 | MYCOPHENOLIC ACID | IC50 | > | 100000.0 | nM | - |