Assay Detail
Functional
CHEMBL1738451
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PUBCHEM_BIOASSAY: Dose Response confirmation of inhibitors of NALP3 in yeast using a Caspase-1-ASC counter screen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2825, AID2832]
67
Total Activities
67
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Category | confirmatory |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NACHT, LRR and PYD domains-containing protein 3 (CHEMBL1741208) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 67 | 5.50 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1490692 | — | — | 1 | 6.25 |
| CHEMBL1331770 | — | — | 1 | 6.19 |
| CHEMBL1703295 | — | — | 1 | 6.18 |
| CHEMBL1076347 | TRICLOCARBAN | 2.0 | 1 | 6.09 |
| CHEMBL236150 | CLIOXANIDE | 2.0 | 1 | 6.09 |
| CHEMBL1525362 | — | — | 1 | 6.05 |
| CHEMBL1366588 | — | — | 1 | 5.98 |
| CHEMBL1457403 | — | — | 1 | 5.97 |
| CHEMBL1559889 | — | — | 1 | 5.92 |
| CHEMBL1427059 | — | — | 1 | 5.91 |
| CHEMBL1336269 | — | — | 1 | 5.84 |
| CHEMBL1343658 | — | — | 1 | 5.81 |
| CHEMBL1571123 | — | — | 1 | 5.78 |
| CHEMBL602526 | — | — | 1 | 5.76 |
| CHEMBL1602195 | — | — | 1 | 5.75 |
| CHEMBL1411435 | — | — | 1 | 5.74 |
| CHEMBL1388722 | — | — | 1 | 5.72 |
| CHEMBL1716490 | — | — | 1 | 5.68 |
| CHEMBL1512568 | — | — | 1 | 5.65 |
| CHEMBL1444685 | — | — | 1 | 5.65 |
| CHEMBL1727095 | — | — | 1 | 5.63 |
| CHEMBL1707377 | — | — | 1 | 5.62 |
| CHEMBL1386774 | — | — | 1 | 5.62 |
| CHEMBL2355051 | CLOMIPHENE | 4.0 | 1 | 5.62 |
| CHEMBL1347185 | — | — | 1 | 5.57 |
| CHEMBL1329507 | — | — | 1 | 5.57 |
| CHEMBL1530042 | — | — | 1 | 5.56 |
| CHEMBL1574982 | — | — | 1 | 5.53 |
| CHEMBL1596325 | — | — | 1 | 5.53 |
| CHEMBL1339245 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1490692 | — | IC50 | = | 566.0 | nM | 6.25 |
| CHEMBL1331770 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL1703295 | — | IC50 | = | 665.0 | nM | 6.18 |
| CHEMBL1076347 | TRICLOCARBAN | IC50 | = | 805.0 | nM | 6.09 |
| CHEMBL236150 | CLIOXANIDE | IC50 | = | 813.0 | nM | 6.09 |
| CHEMBL1525362 | — | IC50 | = | 881.0 | nM | 6.05 |
| CHEMBL1366588 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL1457403 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL1559889 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL1427059 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL1336269 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL1343658 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL1571123 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL602526 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL1602195 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL1411435 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL1388722 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL1716490 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL1512568 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL1444685 | — | IC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL1727095 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL1707377 | — | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL1386774 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL2355051 | CLOMIPHENE | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL1329507 | — | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL1347185 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1530042 | — | IC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL1574982 | — | IC50 | = | 2980.0 | nM | 5.53 |
| CHEMBL1596325 | — | IC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL1339245 | — | IC50 | = | 3110.0 | nM | 5.51 |
| CHEMBL1529733 | — | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL1505335 | — | IC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL1563728 | — | IC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL2001888 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1532568 | — | IC50 | = | 3370.0 | nM | 5.47 |
| CHEMBL1505307 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL1994635 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL1412902 | — | IC50 | = | 4030.0 | nM | 5.39 |
| CHEMBL1732520 | — | IC50 | = | 4290.0 | nM | 5.37 |
| CHEMBL1256359 | ALAPROCLATE HYDROCHLORIDE | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL1447669 | — | IC50 | = | 4350.0 | nM | 5.36 |
| CHEMBL1711405 | — | IC50 | = | 4440.0 | nM | 5.35 |
| CHEMBL1381195 | — | IC50 | = | 4580.0 | nM | 5.34 |
| CHEMBL2000196 | — | IC50 | = | 4550.0 | nM | 5.34 |
| CHEMBL1398317 | — | IC50 | = | 4540.0 | nM | 5.34 |
| CHEMBL1507547 | — | IC50 | = | 4780.0 | nM | 5.32 |
| CHEMBL1363164 | — | IC50 | = | 4860.0 | nM | 5.31 |
| CHEMBL1447078 | — | IC50 | = | 4850.0 | nM | 5.31 |
| CHEMBL1585618 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL16312 | 4'-METHOXYFLAVONE | IC50 | = | 5400.0 | nM | 5.27 |