Compound Detail

CHEMBL236150

CLIOXANIDE

🧪 Phase II

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🧪 Phase II

CC(=O)Oc1c(I)cc(I)cc1C(=O)Nc1ccc(Cl)cc1

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL236150
Name	CLIOXANIDE
Phase	Phase II
Structure Type	MOL
InChI Key	ICKMASVVMCGZLR-UHFFFAOYSA-N

CI-633 Clioxanida Clioxanide CN 59,567 CN 59567 CN-59567 NSC-233846 SYD-230

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

541.5

MW (Da)

4.73

ALogP

HBA

HBD

55.4

PSA (Å²)

0.35

QED

Ro5 Violations

Rot. Bonds

Molecule Type	Small molecule
Chirality	Achiral

USAN Stem	-oxanide
USAN Year	1968

EC50 3 meas. best 6.42

IC50 2 meas. best 6.09

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Streptococcus sp. 'group A' CHEMBL612389	EC50	6.42	6.42	377.0	1
Streptokinase A CHEMBL1293228	EC50	6.41	6.41	394.0	1
Streptococcus CHEMBL612313	EC50	6.12	6.12	760.0	1
NACHT, LRR and PYD domains-containing protein 3 CHEMBL1741208	IC50	6.09	5.94	813.0	2

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Streptococcus sp. 'group A'	EC50	=	377.0	nM	6.42	PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Iden...	-
Streptokinase A	EC50	=	394.0	nM	6.41	PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Iden...	-
Streptococcus	EC50	=	760.0	nM	6.12	PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Response HTS to Identify...	-
NACHT, LRR and PYD domains-containing protein 3	IC50	=	813.0	nM	6.09	PUBCHEM_BIOASSAY: Dose Response confirmation of inhibitors of NALP3 in yeast usi...	-
NACHT, LRR and PYD domains-containing protein 3	IC50	=	1610.0	nM	5.79	PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for the identification of i...	-

PubMed	DOI	Target Context	# Activities
17975903	10.1021/jm070741b	Unchecked	8

Data from ChEMBL 36 via Core Engine