Compound Detail
CHEMBL1242
PHENAZOPYRIDINE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1242 |
| Name | PHENAZOPYRIDINE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | QPFYXYFORQJZEC-FOCLMDBBSA-N |
| Therapeutic | ✓ Yes |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
20
Publications
3
Known Names
3
Indications
Molecular Properties
213.2
MW (Da)
2.66
ALogP
5
HBA
2
HBD
89.7
PSA (Ų)
0.75
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1987 |
| Availability | Withdrawn |
| Chirality | Achiral |
Indications
Dysuria Pain Urinary Retention
ATC Classification
G04BX06
phenazopyridine
Level 1: GENITO URINARY SYSTEM AND SEX HORMONES
Level 2: UROLOGICALS
Drug Warnings
Withdrawn
carcinogenicity
unacceptable benefit to risk ratio (carcinogenic potential)
Activity Summary
EC50 2 meas. best 5.72
IC50 1 meas. best 4.55
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Human coronavirus OC43 CHEMBL5209665 | EC50 | 5.72 | 5.72 | 1900.0 | 1 |
| Unchecked CHEMBL612545 | EC50 | 5.7 | 5.7 | 2020.0 | 1 |
| SARS-CoV-2 CHEMBL4303835 | IC50 | 4.55 | 4.55 | 28000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Human coronavirus OC43 | EC50 | = | 1900.0 | nM | 5.72 | Antiviral activity against wild type HCoV-OC43 infected in BHK-21 cells incubate... | 32845145 |
| Unchecked | EC50 | = | 2020.0 | nM | 5.7 | Antiviral activity against HCoV-NL63 infected in Rhesus macaque LLC-MK2 cells in... | 32845145 |
| SARS-CoV-2 | IC50 | = | 28000.0 | nM | 4.55 | Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in ... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.5281/zenodo.13943903 | ADMET | 88 |
| 31158845 | 10.1038/s41586-019-1291-3 | ADMET | 81 |
| 15646539 | 10.1016/s0399-8320(04)95062-2 | Unchecked | 11 |
| 15646539 | 10.1016/s0399-8320(04)95062-2 | NON-PROTEIN TARGET | 8 |
| 32845145 | 10.1021/acs.jmedchem.0c00626 | Unchecked | 3 |
| 31158845 | 10.1038/s41586-019-1291-3 | SGNH hydrolase-type esterase domain-containing protein | 3 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 3 |
| 31158845 | 10.1038/s41586-019-1291-3 | Flavodoxin | 3 |
| 37468498 | 10.1038/s41467-023-40064-9 | Alpha-2A adrenergic receptor | 3 |
| 37468498 | 10.1038/s41467-023-40064-9 | 5-hydroxytryptamine receptor 2B | 3 |
| 37468498 | 10.1038/s41467-023-40064-9 | Gamma-aminobutyric acid receptor subunit alpha-1 | 3 |
| 31158845 | 10.1038/s41586-019-1291-3 | General stress protein | 3 |
| 37468498 | 10.1038/s41467-023-40064-9 | Alpha-1A adrenergic receptor | 3 |
| 37468498 | 10.1038/s41467-023-40064-9 | Muscarinic acetylcholine receptor M2 | 3 |
| 37468498 | 10.1038/s41467-023-40064-9 | D(1A) dopamine receptor | 3 |
| 37468498 | 10.1038/s41467-023-40064-9 | Cannabinoid receptor 1 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Amine oxidase [flavin-containing] A | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Prostaglandin G/H synthase 1 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Gamma-aminobutyric acid receptor subunit alpha-1/alpha-2/beta-2/gamma-2 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A | 2 |
Data from ChEMBL 36 via Core Engine