Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL5209665 Target Snapshot

Human coronavirus OC43 · ORGANISM · Human coronavirus OC43

Back to Search Search this target Browse approvals Evidence Card
251Compounds
61Assays
12Approved Drugs
228.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Research home Demo workspace
Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Human coronavirus OC43 as ChEMBL target CHEMBL5209665. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Human coronavirus OC43
ORGANISM · Human coronavirus OC43
As of 2026-09-13
ChEMBL target ID
CHEMBL5209665
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Human coronavirus OC43 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameHuman coronavirus OC43
Target TypeORGANISM
OrganismHuman coronavirus OC43
ChEMBL ↗ NCBI Taxonomy ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHuman coronavirus OC43
UniProt AccessionN/A

Human coronavirus OC43

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Human coronavirus OC43.

Review nameHuman coronavirus OC43
OrganismHuman coronavirus OC43
Clinical Profile

Clinical Phase Distribution

12
Approved
2
Phase III
Assay Mix

Activity Type Distribution

IC509.0
EC50219.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4065616 8.0 EC50 10.0 Approved
CHEMBL4802135 7.16 EC50 70.0 Approved
CHEMBL5191060 7.05 EC50 90.0 Preclinical
CHEMBL5646566 7.05 EC50 90.0 Preclinical
CHEMBL5532059 7.0 EC50 100.0 Preclinical
CHEMBL5647387 7.0 EC50 100.0 Preclinical
CHEMBL5439916 6.95 EC50 112.0 Preclinical
CHEMBL5565685 6.92 EC50 120.0 Preclinical
CHEMBL5646608 6.92 EC50 120.0 Preclinical
CHEMBL5419985 6.87 EC50 136.0 Preclinical
Distribution

pChEMBL Value Distribution

33
5.0
43
5.5
29
6.0
29
6.5
6
7.0
0
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

NIRMATRELVIR
CHEMBL4802135
Approved 2023
Properties Compare Identifier
REMDESIVIR
CHEMBL4065616
Approved 2020
Properties Compare Identifier
CHLOROQUINE PHOSPHATE
CHEMBL58510
Approved 1949
Properties Compare Identifier
CHLOROQUINE
CHEMBL76
Approved 1949
Properties Compare Identifier
EMETINE
CHEMBL50588
Properties Compare Identifier
Assay Landscape

Assay Landscape

61
Total Assays
171
Tested Compounds
1
Assay Types
Functional — 61 assays, 171 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 50 154 5.7
cell-based format 10 16 6.1
assay format 1 1 6.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine