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Evidence Snapshot

Human coronavirus OC43

CHEMBL5209665 ORGANISM Human coronavirus OC43
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T20:45:05Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL5209665
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Human coronavirus OC43 as ChEMBL target CHEMBL5209665. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Human coronavirus OC43
ORGANISM · Human coronavirus OC43
As of 2026-09-13
ChEMBL target ID
CHEMBL5209665
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Human coronavirus OC43 matters

As of 2026-09-13

Human coronavirus OC43 is reviewed as Human coronavirus OC43; the current evidence base includes 12 approved drugs, 251 compounds, and 61 assays, with lead potency reaching pChEMBL 8.0.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 12 approved drugs, 251 compounds, and 61 assays for this target. The dominant activity type is EC50. CHEMBL4065616 is the current potency anchor at pChEMBL 8.0.

Use CHEMBL4065616 as the tractability anchor when discussing potency (pChEMBL 8.0).

Activity source · ChEMBL 36 via Core Engine
12 approved pChEMBL 8.0
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Human coronavirus OC43 matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

251
Total Compounds
61
Total Assays
12
Approved Drugs
IC50: 9.0, EC50: 219.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL4065616
 8.0 EC50 Approved
No preferred name
CHEMBL4802135
 7.2 EC50 Approved
No preferred name
CHEMBL5191060
 7.0 EC50 —
No preferred name
CHEMBL5646566
 7.0 EC50 —
No preferred name
CHEMBL5532059
 7.0 EC50 —

Approved Drugs

Structure Compound First Approval
NIRMATRELVIR
CHEMBL4802135
 2023
REMDESIVIR
CHEMBL4065616
 2020
CHLOROQUINE PHOSPHATE
CHEMBL58510
 1949
CHLOROQUINE
CHEMBL76
 1949
EMETINE
CHEMBL50588
 —
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T20:45:05Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL5209665