Assay Detail
Binding
CHEMBL5337908
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of glucocorticoid receptor (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The medicinal chemistry evolution of antibody-drug conjugates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.78 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2040682 | CICLESONIDE | 4.0 | 1 | 8.70 |
| CHEMBL4594374 | DESISOBUTYRYLCICLESONIDE | -1.0 | 1 | 8.70 |
| CHEMBL5433271 | — | — | 1 | 8.52 |
| CHEMBL5417330 | — | — | 1 | 8.30 |
| CHEMBL5439877 | — | — | 1 | 7.47 |
| CHEMBL5435559 | — | — | 1 | 7.28 |
| CHEMBL5413057 | — | — | 1 | 7.20 |
| CHEMBL5396710 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2040682 | CICLESONIDE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4594374 | DESISOBUTYRYLCICLESONIDE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5433271 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5417330 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5439877 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5435559 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL5413057 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL5396710 | — | IC50 | = | 911.0 | nM | 6.04 |