Compound Detail
CHEMBL4104286
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C[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2c(cnn2-c2ccc(F)cc2)c1)c1ccc2c(c1)OCCO2
Basic Information
| ChEMBL ID | CHEMBL4104286 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OAYGXXRNERUMAL-LMKMVOKYSA-N |
1
Targets
2
Activities
1
Assay Types
7
PK Parameters
5
Publications
0
Known Names
Molecular Properties
511.5
MW (Da)
5.22
ALogP
6
HBA
1
HBD
74.6
PSA (Ų)
0.37
QED
2
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 10.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucocorticoid receptor CHEMBL2034 | IC50 | 10.7 | 10.4 | 0.0 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 6138.0 | ng.hr.mL-1 | Rattus norvegicus |
| CL | 42.0 | mL.min-1.kg-1 | Rattus norvegicus |
| Cmax | 30.0 | nM | Rattus norvegicus |
| F | 11.0 | % | Rattus norvegicus |
| MRT | 8.8 | hr | Rattus norvegicus |
| T1/2 | 7.4 | hr | Rattus norvegicus |
| T1/2 | 8.9 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | IC50 | = | 0.02 | nM | 10.7 | Transrepression of glucocorticoid receptor in PMA-stimulated human ChaGoK1 cells... | 28937774 |
| Glucocorticoid receptor | IC50 | = | 0.08 | nM | 10.1 | Transrepression of glucocorticoid receptor in human PBMC assessed as inhibition ... | 28937774 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28937774 | 10.1021/acs.jmedchem.7b01215 | Rattus norvegicus | 5 |
| 28937774 | 10.1021/acs.jmedchem.7b01215 | Lung | 5 |
| 28937774 | 10.1021/acs.jmedchem.7b01215 | Glucocorticoid receptor | 4 |
| 28937774 | 10.1021/acs.jmedchem.7b01215 | ADMET | 2 |
| 28937774 | 10.1021/acs.jmedchem.7b01215 | No relevant target | 2 |
Data from ChEMBL 36 via Core Engine