Cytochrome P450 3A5 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P20815. Use UniProt P20815 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P20815 as the stable identity anchor, then attach disease evidence before program review.
Cytochrome P450 3A5
Review this target as Cytochrome P450 3A5, mapped to UniProt P20815. Sequence length is 502 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cytochrome P450 3A5 as ChEMBL target CHEMBL3019, mapped to UniProt P20815. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Cytochrome P450 3A5 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P20815 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cytochrome P450 3A5 |
| UniProt Accession | P20815 |
| Component Type | Protein |
| Sequence Length | 502 aa |
Cytochrome P450 3A5
Review this target as Cytochrome P450 3A5, mapped to UniProt P20815. Sequence length is 502 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1159650 | 7.68 | IC50 | 21.0 | Approved |
| CHEMBL1159650 | 7.0 | Kd | 100.0 | Approved |
| CHEMBL157101 | 6.92 | IC50 | 120.0 | Approved |
| CHEMBL163 | 6.92 | Ki | 120.0 | Approved |
| CHEMBL269732 | 6.85 | IC50 | 140.0 | Approved |
| CHEMBL190461 | 6.72 | Ki | 190.0 | Approved |
| CHEMBL116 | 6.7 | Ki | 200.0 | Approved |
| CHEMBL3422028 | 6.25 | IC50 | 556.0 | Preclinical |
| CHEMBL584 | 6.24 | Ki | 570.0 | Approved |
| CHEMBL2386285 | 6.14 | IC50 | 723.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 162 | 38 | 5.1 |
| assay format | 49 | 3 | 6.2 |
| microsome format | 23 | 0 | — |
| cell-based format | 17 | 1 | 6.7 |
| tissue-based format | 6 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 7 | 2 | 5.8 |
| cell-based format | 4 | 2 | 6.9 |
| microsome format | 2 | 0 | — |
| single protein format | 2 | 3 | 6.0 |