Assay Detail
ADMET
CHEMBL4011671
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human BSEP expressed in baculovirus infected sf21 cell plasma membrane vesicles assessed as reduction in ATP-dependent [3H]-taurocholate uptake in to vesicles after 5 mins by microbeta filtration method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Subcellular | Plasma Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.06 | 5.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1159650 | CLOBETASOL PROPIONATE | 4.0 | 1 | 5.07 |
| CHEMBL54349 | ALPIDEM | 4.0 | 1 | 5.04 |
| CHEMBL95889 | BETAINE | 4.0 | 1 | - |
| CHEMBL372795 | STREPTOMYCIN | 4.0 | 1 | - |
| CHEMBL35 | FUROSEMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1159650 | CLOBETASOL PROPIONATE | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL54349 | ALPIDEM | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL95889 | BETAINE | IC50 | > | 1000000.0 | nM | - |
| CHEMBL372795 | STREPTOMYCIN | IC50 | > | 1000000.0 | nM | - |
| CHEMBL35 | FUROSEMIDE | IC50 | > | 1000000.0 | nM | - |