Assay Detail
Binding
CHEMBL685138
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive displacement of [3H]dexamethasone from glucocorticoid receptor of rat liver cytosol
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and evaluation of antiinflammatory activities of a series of corticosteroid 17 alpha-esters containing a functional group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.16 | 8.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1159650 | CLOBETASOL PROPIONATE | 4.0 | 1 | 8.50 |
| CHEMBL315931 | — | — | 1 | 8.29 |
| CHEMBL1200384 | BETAMETHASONE DIPROPIONATE | 4.0 | 1 | 8.28 |
| CHEMBL81387 | — | — | 1 | 8.01 |
| CHEMBL83845 | — | — | 1 | 7.97 |
| CHEMBL311802 | — | — | 1 | 7.92 |
| CHEMBL311457 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1159650 | CLOBETASOL PROPIONATE | IC50 | = | 3.17 | nM | 8.50 |
| CHEMBL315931 | — | IC50 | = | 5.18 | nM | 8.29 |
| CHEMBL1200384 | BETAMETHASONE DIPROPIONATE | IC50 | = | 5.25 | nM | 8.28 |
| CHEMBL81387 | — | IC50 | = | 9.68 | nM | 8.01 |
| CHEMBL83845 | — | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL311802 | — | IC50 | = | 12.1 | nM | 7.92 |
| CHEMBL311457 | — | IC50 | > | 150.0 | nM | - |