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Evidence Snapshot

Glucocorticoid receptor

CHEMBL3368 SINGLE PROTEIN Rattus norvegicus
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:30:21Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL3368
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Glucocorticoid receptor as ChEMBL target CHEMBL3368, mapped to UniProt P06536. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Glucocorticoid receptor
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL3368
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P06536
Glucocorticoid receptor
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Glucocorticoid receptor matters

As of 2026-09-13

Glucocorticoid receptor is reviewed as Glucocorticoid receptor (UniProt P06536); the current evidence base includes 13 approved drugs, 399 compounds, and 163 assays, with lead potency reaching pChEMBL 10.0.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 13 approved drugs, 399 compounds, and 163 assays for this target. The dominant activity type is IC50. CHEMBL3666814 is the current potency anchor at pChEMBL 10.0.

Use CHEMBL3666814 as the tractability anchor when discussing potency (pChEMBL 10.0).

Activity source · ChEMBL 36 via Core Engine
13 approved pChEMBL 10.0
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Glucocorticoid receptor matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P06536, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

399
Total Compounds
163
Total Assays
13
Approved Drugs
IC50: 217.0, KI: 26.0, EC50: 112.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL3666814
 10.0 IC50 —
No preferred name
CHEMBL4072756
 9.8 IC50 Clinical
No preferred name
CHEMBL1473
 9.8 IC50 Approved
No preferred name
CHEMBL4863316
 9.8 IC50 —
No preferred name
CHEMBL433586
 9.7 EC50 —

Approved Drugs

Structure Compound First Approval
MIFEPRISTONE
CHEMBL1276308
 2000
BUDESONIDE
CHEMBL1370
 1994
FLUTICASONE PROPIONATE
CHEMBL1473
 1990
CLOBETASOL PROPIONATE
CHEMBL1159650
 1985
BETAMETHASONE DIPROPIONATE
CHEMBL1200384
 1975
DEXAMETHASONE
CHEMBL384467
 1958
PREDNISOLONE
CHEMBL131
 1955
HYDROCORTISONE
CHEMBL389621
 1952
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:30:21Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL3368