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Compound Detail

CHEMBL1200384

BETAMETHASONE DIPROPIONATE
💊 Approved Drug
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💊 Approved Drug
CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1200384
Name BETAMETHASONE DIPROPIONATE
Phase Approved
Structure Type MOL
InChI Key CIWBQSYVNNPZIQ-XYWKZLDCSA-N
Therapeutic ✓ Yes

Known Names

Alphatrex Betamethasone (as dipropionate) Betamethasone 17,21-dipropionate Betamethasone dipropionate Betamethasone dipropionate component of enstilar Betamethasone dipropionate component of leo-90100 Betamethasone dipropionate component of lotrisone Betamethasone dipropionate component of taclonex Betamethasone dipropionate component of wynzora Diprolene Diprolene af Diprosone +7 more
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
20
Publications
19
Known Names
10
Indications
1
Mechanisms

Molecular Properties

504.6
MW (Da)
3.82
ALogP
7
HBA
1
HBD
107.0
PSA (Ų)
0.55
QED
1
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1975
Availability Prescription
Chirality Single Enantiomer

Routes of Administration

Topical
USAN Year 1974

Extended Properties

Molecular Formula C28H37FO7
MW 504.60
Aromatic Rings 0
Heavy Atoms 36
NP-Likeness 1.75

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Glucocorticoid receptor agonist AGONIST Glucocorticoid receptor ✓ ✓

Indications

Infections Psoriasis Psoriasis Skin Diseases Gout Periarthritis Lichen Planus, Oral Sinusitis Dermatitis, Atopic Oral Submucous Fibrosis

Activity Summary

IC50 1 meas. best 8.28

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Glucocorticoid receptor
CHEMBL3368
 IC50 8.28 8.28 5.2 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Glucocorticoid receptor IC50 = 5.25 nM 8.28 Competitive displacement of [3H]dexamethasone from glucocorticoid receptor of ra... 1875343

Literature References

PubMed DOI Target Context # Activities
16472241 10.2174/1570163043334794 Hepatotoxicity 18
2362263 10.1021/jm00169a004 Mus musculus 15
- 10.6019/CHEMBL4808148 Histone deacetylase 6 3
24400858 10.1021/np400704b Mus musculus 2
37468498 10.1038/s41467-023-40064-9 Gamma-aminobutyric acid receptor subunit alpha-1 2
37468498 10.1038/s41467-023-40064-9 Nuclear receptor subfamily 1 group I member 2 2
37468498 10.1038/s41467-023-40064-9 Alpha-2A adrenergic receptor 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2A 2
- 10.6019/CHEMBL4651402 SARS-CoV-2 2
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M2 2
37468498 10.1038/s41467-023-40064-9 Androgen receptor 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 1A 2
37468498 10.1038/s41467-023-40064-9 Cannabinoid receptor 1 2
37468498 10.1038/s41467-023-40064-9 Alpha-1A adrenergic receptor 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2B 2
30237123 10.1016/j.ejmech.2018.09.033 Mus musculus 1
21381684 10.1021/np100701s Mus musculus 1
1875343 10.1021/jm00112a023 Glucocorticoid receptor 1
1875343 10.1021/jm00112a023 Rattus norvegicus 1

Data from ChEMBL 36 via Core Engine