Review anchor
Cytochrome P450 3A4
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
Evidence Snapshot
Cytochrome P450 3A4
CHEMBL340
SINGLE PROTEIN
Homo sapiens
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cytochrome P450 3A4 as ChEMBL target CHEMBL340, mapped to UniProt P08684. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL340
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P08684
Cytochrome P450 3A4
UniProt accession via ChEMBL component mapping
As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Cytochrome P450 3A4 matters
Cytochrome P450 3A4 is reviewed as Cytochrome P450 3A4 (UniProt P08684); the current evidence base includes 127 approved drugs, 35011 compounds, and 5360 assays, with lead potency reaching pChEMBL 10.7.
Protein context
Cytochrome P450 3A4
Cytochrome P450 3A4 Sequence length is 503 aa.
Review this target as Cytochrome P450 3A4, mapped to UniProt P08684. Sequence length is 503 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt P08684
Protein
Disease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 127 approved drugs, 35011 compounds, and 5360 assays for this target. The dominant activity type is IC50. CHEMBL1819091 is the current potency anchor at pChEMBL 10.7.
Use CHEMBL1819091 as the tractability anchor when discussing potency (pChEMBL 10.7).
Activity source · ChEMBL 36 via Core Engine
127 approved
pChEMBL 10.7
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Cytochrome P450 3A4 matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt P08684, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
35011
Total Compounds
5360
Total Assays
127
Approved Drugs
IC50: 13549.0, KI: 1091.0, EC50: 45.0, KD: 18.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL1819091
|
10.7 | Ki | — |
|
|
No preferred name
CHEMBL1819089
|
10.6 | Ki | — |
|
|
No preferred name
CHEMBL3407558
|
10.3 | IC50 | — |
|
|
No preferred name
CHEMBL3125537
|
10.0 | IC50 | — |
|
|
No preferred name
CHEMBL3407554
|
10.0 | IC50 | — |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
LEVOKETOCONAZOLE
CHEMBL295698
|
2021 |
|
|
LEFAMULIN
CHEMBL3291398
|
2019 |
|
|
CANNABIDIOL
CHEMBL190461
|
2018 |
|
|
COBICISTAT
CHEMBL2095208
|
2012 |
|
|
NILOTINIB
CHEMBL255863
|
2007 |
|
|
POSACONAZOLE
CHEMBL1397
|
2005 |
|
|
DULOXETINE
CHEMBL1175
|
2004 |
|
|
APREPITANT
CHEMBL1471
|
2003 |
|
|
ALOSETRON
CHEMBL1110
|
2000 |
|
|
LOPINAVIR
CHEMBL729
|
2000 |
|
|
AMPRENAVIR
CHEMBL116
|
1999 |
|
|
NELFINAVIR
CHEMBL584
|
1997 |
|
|
MIBEFRADIL
CHEMBL45816
|
1997 |
|
|
RITONAVIR
CHEMBL163
|
1996 |
|
|
SAQUINAVIR
CHEMBL114
|
1995 |
|
|
VINORELBINE
CHEMBL553025
|
1994 |
|
|
NEFAZODONE
CHEMBL623
|
1994 |
|
|
TACROLIMUS ANHYDROUS
CHEMBL269732
|
1994 |
|
|
CISAPRIDE
CHEMBL1729
|
1993 |
|
|
ITRACONAZOLE
CHEMBL64391
|
1992 |
|
|
SERTRALINE
CHEMBL809
|
1991 |
|
|
PODOFILOX
CHEMBL61
|
1990 |
|
|
OXICONAZOLE
CHEMBL1262
|
1988 |
|
|
NICARDIPINE
CHEMBL1484
|
1988 |
|
|
CLOBETASOL PROPIONATE
CHEMBL1159650
|
1985 |
|
|
TERFENADINE
CHEMBL17157
|
1985 |
|
|
SULCONAZOLE
CHEMBL1221
|
1985 |
|
|
MIDAZOLAM
CHEMBL655
|
1985 |
|
|
CYCLOSPORINE
CHEMBL160
|
1983 |
|
|
DILTIAZEM
CHEMBL23
|
1982 |
|
|
ECONAZOLE
CHEMBL808
|
1982 |
|
|
VERAPAMIL
CHEMBL6966
|
1981 |
|
|
KETOCONAZOLE
CHEMBL157101
|
1981 |
|
|
TAMOXIFEN
CHEMBL83
|
1977 |
|
|
CLOTRIMAZOLE
CHEMBL104
|
1975 |
|
|
MICONAZOLE
CHEMBL91
|
1974 |
|
|
TESTOSTERONE
CHEMBL386630
|
1972 |
|
|
ERYTHROMYCIN
CHEMBL532
|
1964 |
|
|
METYRAPONE
CHEMBL934
|
1961 |
|
|
ERGOTAMINE
CHEMBL442
|
1948 |
Source Header