Assay Detail

CHEMBL1245533

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antiviral activity against Human immunodeficiency virus 1 subtype BG infected in human MT4 cells assessed as reduction in virus induced cytopathicity

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Human immunodeficiency virus 1 (CHEMBL378) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Human immunodeficiency virus 1

CHEMBL378

Anchored from Assay target.

Protein identity Human immunodeficiency virus 1

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Human immunodeficiency virus 1
Cell Type	MT4
Confidence	1 — Organism
Curated By	Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

Type	ORGANISM
Organism	Human immunodeficiency virus 1

Publication

TMC278, a next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI), active against wild-type and NNRTI-resistant HIV-1.

Azijn H, Tirry I, Vingerhoets J, de Béthune MP, Kraus G, Boven K, Jochmans D, Van Craenenbroeck E, Picchio G, Rimsky LT.
Antimicrob Agents Chemother (2010) 54 : 718 -727
PubMed 19933797 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	4	8.89	9.66

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL175691	RILPIVIRINE	4.0	1	9.66
CHEMBL308954	ETRAVIRINE	4.0	1	9.17
CHEMBL223228	EFAVIRENZ	4.0	1	9.15
CHEMBL57	NEVIRAPINE	4.0	1	7.58

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL175691	RILPIVIRINE	EC50	=	0.22	nM	9.66
CHEMBL308954	ETRAVIRINE	EC50	=	0.67	nM	9.17
CHEMBL223228	EFAVIRENZ	EC50	=	0.7	nM	9.15
CHEMBL57	NEVIRAPINE	EC50	=	25.99	nM	7.58