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Target Snapshot

CHEMBL378 Target Snapshot

Human immunodeficiency virus 1 · ORGANISM · Human immunodeficiency virus 1

27,506Compounds
9,288Assays
103Approved Drugs
52,853.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

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Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Human immunodeficiency virus 1 as ChEMBL target CHEMBL378. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Human immunodeficiency virus 1
ORGANISM · Human immunodeficiency virus 1
As of 2026-09-13
ChEMBL target ID
CHEMBL378
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Human immunodeficiency virus 1 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHuman immunodeficiency virus 1
UniProt AccessionN/A

Human immunodeficiency virus 1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Human immunodeficiency virus 1.

Review nameHuman immunodeficiency virus 1
OrganismHuman immunodeficiency virus 1
Clinical Profile

Clinical Phase Distribution

103
Approved
28
Phase III
62
Phase II
16
Phase I
Assay Mix

Activity Type Distribution

IC5014,324.0
KI6.0
EC5038,512.0
KD11.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL57 11.0 EC50 0.01 Approved
CHEMBL2315350 11.0 EC50 0.01 Preclinical
CHEMBL4873511 11.0 EC50 0.01 Preclinical
CHEMBL70663 10.98 EC50 0.0105 Clinical
CHEMBL1643090 10.92 EC50 0.012 Preclinical
CHEMBL1643094 10.92 EC50 0.012 Preclinical
CHEMBL4098771 10.92 IC50 0.012 Preclinical
CHEMBL519846 10.87 EC50 0.0136 Clinical
CHEMBL346387 10.85 IC50 0.014 Preclinical
CHEMBL1811947 10.82 EC50 0.015 Preclinical
Distribution

pChEMBL Value Distribution

4188
5.0
3769
5.5
4635
6.0
4893
6.5
4951
7.0
4747
7.5
4549
8.0
2353
8.5
1305
9.0
398
9.5
pChEMBL
Approved Drugs

Approved Drugs

MAVORIXAFOR
CHEMBL518924
Approved 2024
LENACAPAVIR
CHEMBL4594438
Approved 2022
CABOTEGRAVIR
CHEMBL2403238
Approved 2021
BICTEGRAVIR
CHEMBL3989866
Approved 2018
DORAVIRINE
CHEMBL2364608
Approved 2018
MIDOSTAURIN
CHEMBL608533
Approved 2017
TENOFOVIR ALAFENAMIDE FUMARATE
CHEMBL2364637
Approved 2015
TENOFOVIR ALAFENAMIDE
CHEMBL2107825
Approved 2015
PALBOCICLIB
CHEMBL189963
Approved 2015
ASUNAPREVIR
CHEMBL2105735
Approved 2014
MILTEFOSINE
CHEMBL125
Approved 2014
DOLUTEGRAVIR
CHEMBL1229211
Approved 2013
DOLUTEGRAVIR SODIUM
CHEMBL1213165
Approved 2013
TOFACITINIB
CHEMBL221959
Approved 2012
ELVITEGRAVIR
CHEMBL204656
Approved 2012
RILPIVIRINE
CHEMBL175691
Approved 2011
RUXOLITINIB
CHEMBL1789941
Approved 2011
INGENOL MEBUTATE
CHEMBL1863513
Approved 2010
ROMIDEPSIN
CHEMBL343448
Approved 2009
ETRAVIRINE
CHEMBL308954
Approved 2008
PLERIXAFOR
CHEMBL18442
Approved 2008
RALTEGRAVIR
CHEMBL254316
Approved 2007
MARAVIROC
CHEMBL256907
Approved 2007
RALTEGRAVIR POTASSIUM
CHEMBL518520
Approved 2007
DARUNAVIR
CHEMBL1323
Approved 2006
VORINOSTAT
CHEMBL98
Approved 2006
SORAFENIB
CHEMBL1336
Approved 2005
TIPRANAVIR
CHEMBL222559
Approved 2005
ENTECAVIR
CHEMBL5314362
Approved 2005
ATAZANAVIR
CHEMBL1163
Approved 2003
EMTRICITABINE
CHEMBL885
Approved 2003
ENFUVIRTIDE
CHEMBL525076
Approved 2003
ADEFOVIR DIPIVOXIL
CHEMBL922
Approved 2002
TENOFOVIR DISOPROXIL
CHEMBL1538
Approved 2001
TENOFOVIR DISOPROXIL FUMARATE
CHEMBL1486
Approved 2001
LOPINAVIR
CHEMBL729
Approved 2000
SIROLIMUS
CHEMBL413
Approved 1999
AMPRENAVIR
CHEMBL116
Approved 1999
EFAVIRENZ
CHEMBL223228
Approved 1998
ABACAVIR SULFATE
CHEMBL4303288
Approved 1998
ABACAVIR
CHEMBL1380
Approved 1998
DELAVIRDINE MESYLATE
CHEMBL929
Approved 1997
NELFINAVIR
CHEMBL584
Approved 1997
DELAVIRDINE
CHEMBL593
Approved 1997
INDINAVIR SULFATE
CHEMBL1735
Approved 1996
RITONAVIR
CHEMBL163
Approved 1996
GEMCITABINE
CHEMBL888
Approved 1996
NEVIRAPINE
CHEMBL57
Approved 1996
SAQUINAVIR
CHEMBL114
Approved 1995
LAMIVUDINE
CHEMBL141
Approved 1995
Source · ChEMBL 36 via Core Engine