Assay Detail
Functional
CHEMBL834355
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration against human immunodeficiency virus type 1 G190S mutant strain
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.82 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175691 | RILPIVIRINE | 4.0 | 1 | 10.00 |
| CHEMBL70663 | DAPIVIRINE | 3.0 | 1 | 8.70 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 6.56 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175691 | RILPIVIRINE | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL70663 | DAPIVIRINE | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 275.0 | nM | 6.56 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 1000.0 | nM | 6.00 |