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Target Snapshot

CHEMBL613758 Target Snapshot

Human immunodeficiency virus · ORGANISM · Human immunodeficiency virus

2,004Compounds
532Assays
36Approved Drugs
2,339.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

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Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Human immunodeficiency virus as ChEMBL target CHEMBL613758. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Human immunodeficiency virus
ORGANISM · Human immunodeficiency virus
As of 2026-09-13
ChEMBL target ID
CHEMBL613758
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Human immunodeficiency virus still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHuman immunodeficiency virus
UniProt AccessionN/A

Human immunodeficiency virus

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Human immunodeficiency virus.

Review nameHuman immunodeficiency virus
OrganismHuman immunodeficiency virus
Clinical Profile

Clinical Phase Distribution

36
Approved
6
Phase III
13
Phase II
Assay Mix

Activity Type Distribution

IC50906.0
KI6.0
EC501,427.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5314362 10.0 EC50 0.1 Approved
CHEMBL1078231 9.74 IC50 0.18 Preclinical
CHEMBL5397495 9.51 IC50 0.31 Preclinical
CHEMBL5395699 9.49 IC50 0.32 Preclinical
CHEMBL5412528 9.49 IC50 0.32 Preclinical
CHEMBL175691 9.46 IC50 0.35 Approved
CHEMBL269559 9.4 EC50 0.4 Preclinical
CHEMBL2403229 9.4 IC50 0.4 Preclinical
CHEMBL223228 9.3 EC50 0.5 Approved
CHEMBL223228 9.3 IC50 0.5 Approved
Distribution

pChEMBL Value Distribution

125
5.0
131
5.5
161
6.0
197
6.5
262
7.0
253
7.5
204
8.0
124
8.5
65
9.0
2
9.5
pChEMBL
Approved Drugs

Approved Drugs

CABOTEGRAVIR
CHEMBL2403238
Approved 2021
DOLUTEGRAVIR
CHEMBL1229211
Approved 2013
ELVITEGRAVIR
CHEMBL204656
Approved 2012
RILPIVIRINE
CHEMBL175691
Approved 2011
ETRAVIRINE
CHEMBL308954
Approved 2008
RALTEGRAVIR
CHEMBL254316
Approved 2007
RALTEGRAVIR POTASSIUM
CHEMBL518520
Approved 2007
DARUNAVIR
CHEMBL1323
Approved 2006
TIPRANAVIR
CHEMBL222559
Approved 2005
ENTECAVIR
CHEMBL5314362
Approved 2005
EMTRICITABINE
CHEMBL885
Approved 2003
ATAZANAVIR
CHEMBL1163
Approved 2003
LOPINAVIR
CHEMBL729
Approved 2000
AMPRENAVIR
CHEMBL116
Approved 1999
ABACAVIR
CHEMBL1380
Approved 1998
EFAVIRENZ
CHEMBL223228
Approved 1998
NELFINAVIR
CHEMBL584
Approved 1997
RITONAVIR
CHEMBL163
Approved 1996
NEVIRAPINE
CHEMBL57
Approved 1996
SAQUINAVIR
CHEMBL114
Approved 1995
LAMIVUDINE
CHEMBL141
Approved 1995
STAVUDINE
CHEMBL991
Approved 1994
ZALCITABINE
CHEMBL853
Approved 1992
ZIDOVUDINE
CHEMBL129
Approved 1987
Assay Landscape

Assay Landscape

532
Total Assays
1,168
Tested Compounds
2
Assay Types
Functional — 527 assays, 1,168 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 525 1,167 7.0
assay format 1 1 8.0
cell-based format 1 0
ADME — 5 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 5 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine