Skip to main content
Evidence Snapshot

Cytochrome P450 2C9

CHEMBL3397 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T05:02:20Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL3397
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Cytochrome P450 2C9 as ChEMBL target CHEMBL3397, mapped to UniProt P11712. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Cytochrome P450 2C9
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL3397
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P11712
Cytochrome P450 2C9
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Cytochrome P450 2C9 matters

As of 2026-09-13

Cytochrome P450 2C9 is reviewed as Cytochrome P450 2C9 (UniProt P11712); the current evidence base includes 90 approved drugs, 26603 compounds, and 3156 assays, with lead potency reaching pChEMBL 9.3.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 90 approved drugs, 26603 compounds, and 3156 assays for this target. The dominant activity type is IC50. CHEMBL16596 is the current potency anchor at pChEMBL 9.3.

Use CHEMBL16596 as the tractability anchor when discussing potency (pChEMBL 9.3).

Activity source · ChEMBL 36 via Core Engine
90 approved pChEMBL 9.3
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Cytochrome P450 2C9 matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P11712, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

26603
Total Compounds
3156
Total Assays
90
Approved Drugs
IC50: 7307.0, KI: 1002.0, EC50: 36.0, KD: 1.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL16596
 9.3 IC50 Clinical
No preferred name
CHEMBL220360
 9.0 IC50 Clinical
No preferred name
CHEMBL1825089
 9.0 IC50 —
No preferred name
CHEMBL38958
 9.0 IC50 —
No preferred name
CHEMBL1922663
 8.8 IC50 —

Approved Drugs

Structure Compound First Approval
RILPIVIRINE
CHEMBL175691
 2011
ETRAVIRINE
CHEMBL308954
 2008
RIMONABANT
CHEMBL111
 2006
RITONAVIR
CHEMBL163
 1996
FLUVASTATIN
CHEMBL2220442
 1993
NIMODIPINE
CHEMBL1428
 1988
NICARDIPINE
CHEMBL1484
 1988
SULCONAZOLE
CHEMBL1221
 1985
ECONAZOLE
CHEMBL808
 1982
SULFAPHENAZOLE
CHEMBL1109
 1982
DANAZOL
CHEMBL1479
 1976
CLOTRIMAZOLE
CHEMBL104
 1975
MICONAZOLE
CHEMBL91
 1974
TOLBUTAMIDE
CHEMBL782
 1961
TROPICAMIDE
CHEMBL1200604
 1960
DICUMAROL
CHEMBL1466
 1944
BENZBROMARONE
CHEMBL388590
 —
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T05:02:20Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL3397