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Assay Detail

CHEMBL819590

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Compound was evaluated for its inhibitory activity against CO(cyclooxygenase)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Cyclooxygenase (CHEMBL2095157)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Synthesis and cyclooxygenase and 5-lipoxygenase inhibitory activity of some thiazolidene-4-one analogs of meclofenamic acid
Boschelli DH, Connor DT, Kuipers PJ, Wright CD
Bioorg Med Chem Lett (1992) 2 : 705 -708
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 6.11 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL509 MECLOFENAMIC ACID 4.0 1 7.00
CHEMBL162840 1 5.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL509 MECLOFENAMIC ACID IC50 = 100.0 nM 7.00
CHEMBL162840 IC50 = 6000.0 nM 5.22