Assay Detail
Binding
CHEMBL764932
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of prostaglandin G/H synthase by measuring the reduction of prostaglandin F2-alpha in intact basophilic rat leukemia cells
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Design of 5-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazoles, -1,3,4-oxadiazoles, and -1,2,4-triazoles as orally-active, nonulcerogenic antiinflammatory agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.98 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12594 | E-5110 | — | 1 | 7.40 |
| CHEMBL509 | MECLOFENAMIC ACID | 4.0 | 1 | 7.00 |
| CHEMBL417073 | — | — | 1 | 6.89 |
| CHEMBL8562 | — | — | 1 | 6.82 |
| CHEMBL16828 | — | — | 1 | 6.46 |
| CHEMBL12532 | — | — | 1 | 6.39 |
| CHEMBL2079592 | — | — | 1 | 6.19 |
| CHEMBL12483 | — | — | 1 | 6.11 |
| CHEMBL122193 | — | — | 1 | 6.10 |
| CHEMBL12302 | — | — | 1 | 5.82 |
| CHEMBL12219 | — | — | 1 | 5.62 |
| CHEMBL16977 | — | — | 1 | 5.60 |
| CHEMBL276916 | — | — | 1 | 5.43 |
| CHEMBL94851 | — | — | 1 | 5.28 |
| CHEMBL12234 | — | — | 1 | 5.26 |
| CHEMBL275909 | — | — | 1 | 5.17 |
| CHEMBL12809 | — | — | 1 | 5.10 |
| CHEMBL273941 | — | — | 1 | 5.03 |
| CHEMBL12395 | — | — | 1 | - |
| CHEMBL275445 | — | — | 1 | - |
| CHEMBL12572 | — | — | 1 | - |
| CHEMBL12154 | — | — | 1 | - |
| CHEMBL273956 | — | — | 1 | - |
| CHEMBL16827 | — | — | 1 | - |
| CHEMBL12371 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12594 | E-5110 | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL509 | MECLOFENAMIC ACID | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL417073 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL8562 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL16828 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL12532 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL2079592 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL12483 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL122193 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL12302 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL12219 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL16977 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL276916 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL94851 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL12234 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL275909 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL12809 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL273941 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL12395 | — | IC50 | > | 32000.0 | nM | - |
| CHEMBL275445 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL12572 | — | IC50 | > | 32000.0 | nM | - |
| CHEMBL12154 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL273956 | — | IC50 | > | 32000.0 | nM | - |
| CHEMBL16827 | — | IC50 | > | 16000.0 | nM | - |
| CHEMBL12371 | — | IC50 | > | 32000.0 | nM | - |