Compound Detail
CHEMBL243580
CARBAZOLE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL243580 |
| Name | CARBAZOLE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UJOBWOGCFQCDNV-UHFFFAOYSA-N |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
13
Publications
0
Known Names
Molecular Properties
167.2
MW (Da)
3.32
ALogP
0
HBA
1
HBD
15.8
PSA (Ų)
0.53
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 5.12
IC50 1 meas. best 5.25
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| U-937 CHEMBL612794 | IC50 | 5.25 | 5.25 | 5560.0 | 1 |
| G-protein coupled receptor 3 CHEMBL4523856 | EC50 | 5.12 | 5.12 | 7600.0 | 1 |
| Bovine viral diarrhea virus 1 CHEMBL612571 | EC50 | 4.19 | 4.19 | 64000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| U-937 | IC50 | = | 5560.0 | nM | 5.25 | Cytotoxicity in UV-irradiated human U937 cells exposed to photosensitizer for 2 ... | 24900465 |
| G-protein coupled receptor 3 | EC50 | = | 7600.0 | nM | 5.12 | Agonist activity at human GPR3 expressed in HEK293 cells assessed as increase in... | 37541631 |
| Bovine viral diarrhea virus 1 | EC50 | = | 64000.0 | nM | 4.19 | Antiviral activity against BVDV infected in MDBK cells assessed as reduction in ... | 18289862 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17236778 | 10.1016/j.bmc.2007.01.007 | Erythrocyte | 10 |
| 35295086 | 10.1021/acsmedchemlett.1c00680 | Staphylococcus aureus | 9 |
| 23376010 | 10.1016/j.bmc.2013.01.012 | Tyrosinase | 5 |
| 23376010 | 10.1016/j.bmc.2013.01.012 | Unchecked | 5 |
| 23376010 | 10.1016/j.bmc.2013.01.012 | ADMET | 4 |
| 37541631 | 10.1016/j.bmcl.2023.129427 | G-protein coupled receptor 3 | 2 |
| 18289862 | 10.1016/j.bmc.2008.01.052 | Bovine viral diarrhea virus 1 | 1 |
| 18289862 | 10.1016/j.bmc.2008.01.052 | ADMET | 1 |
| 19056282 | 10.1016/j.bmc.2008.11.040 | ADMET | 1 |
| 20521839 | 10.1021/jm100476d | Kinesin-like protein KIF11 | 1 |
| 24900465 | 10.1021/ml200266v | U-937 | 1 |
| 37467619 | 10.1016/j.ejmech.2023.115627 | Unchecked | 1 |
| 37467619 | 10.1016/j.ejmech.2023.115627 | Cryptococcus neoformans | 1 |
Data from ChEMBL 36 via Core Engine