Assay Detail
Binding
CHEMBL620775
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [14C]arachidonic acid conversion to 5-HETE by broken cell 5-lipoxygenase in vitro (guinea pig PMN)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Enzymic and nonenzymic lipid peroxidation: inhibition by substituted phenoxazines
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.55 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL276850 | PHENOXAZINE | — | 1 | 7.70 |
| CHEMBL273714 | — | — | 1 | 7.46 |
| CHEMBL12681 | — | — | 1 | 7.19 |
| CHEMBL12361 | — | — | 1 | 7.07 |
| CHEMBL12362 | — | — | 1 | 7.06 |
| CHEMBL12456 | — | — | 1 | 6.60 |
| CHEMBL12534 | — | — | 1 | 6.38 |
| CHEMBL274905 | — | — | 1 | 6.21 |
| CHEMBL274541 | — | — | 1 | 6.11 |
| CHEMBL273438 | — | — | 1 | 5.92 |
| CHEMBL11984 | — | — | 1 | 5.55 |
| CHEMBL12816 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL276850 | PHENOXAZINE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL273714 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL12681 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL12361 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL12362 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL12456 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL12534 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL274905 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL274541 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL273438 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL11984 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL12816 | — | IC50 | = | 4600.0 | nM | 5.34 |